Carvedilol vs. metoprolol: Bambanci, kamance, kuma wanne ne mafi alheri a gare ku
Magunguna vs. AbokiBayanin magunguna & manyan bambance-bambance | Yanayin da aka bi | Inganci | Inshorar inshora da kwatancen farashi | Sakamakon sakamako | Hadin magunguna | Gargadi | Tambayoyi
Carvedilol da metoprolol su ne magungunan likitanci da ake amfani da su don magance cutar hawan jini (hauhawar jini) da kuma matsalolin zuciya, kamar rashin ƙarfin zuciya. Hakanan za'a iya amfani da waɗannan magunguna don rage haɗarin mutuwa bayan bugun zuciya (inyarction na myocardial).
Dukansu carvedilol da metoprolol an tsara su azaman masu hana beta , wanda aka fi sani da beta-adrenergic blocking agents. Suna aiki ta hanyar toshe masu karɓar beta, wanda ke toshe tasirin norepinephrine da epinephrine a cikin zuciya da jijiyoyin jini. Beta-blockers suna taimakawa rage saukar karfin jini da kuma saurin bugun zuciya don taimakawa danniya akan zuciya.
Carvedilol da metoprolol duka magunguna ne na gama gari. Kodayake suna da kamanceceniya, amma suna da bambance-bambance a cikin sashi, tsarawa, da kuma illa masu illa.
Menene manyan bambance-bambance tsakanin carvedilol da metoprolol?
Ana ɗaukar Carvedilol a matsayin mara zaɓan beta-toshi. Wannan yana nufin cewa carvedilol na iya toshe duka masu karɓar beta-1 da masu karɓar beta-2. Ana samun masu karɓar Beta-1 a cikin zuciya yayin da ake samo masu karɓar beta-2 a cikin tsokoki mai santsi. Carvedilol yana toshe masu karɓar alpha a jijiyoyin jini, wanda ke taimakawa rage saukar karfin jini.
Carvedilol shine sunan gama gari na Coreg. Yawanci ana ɗauka azaman 3.125 MG, 6.25 MG, 12.5 MG, ko 25 MG kwamfutar hannu ta baka sau biyu a rana. Hakanan ana samun Carvedilol a cikin sigar da aka tsawaita (Coreg CR) wanda za'a iya ɗauka sau ɗaya kowace rana.
Metoprolol shine mai zaɓin beta-1 wanda ke toshe masu karɓar beta-1 a cikin zuciya. Koyaya, hakanan yana toshe masu karɓar beta-2, kodayake zuwa ƙaramin mataki. Masu zaɓin beta-masu hanawa na iya samun ɗan bambanci daban-daban idan aka kwatanta da waɗanda ba zaɓaɓɓun beta-blockers ba.
Metoprolol ya shigo da sifofin gishiri daban-daban: metoprolol tartrate da metoprolol succinate . Metoprolol tartrate, wanda aka san shi da sunan mai suna Lopressor, ana fitar da kwamfutar hannu ta kai tsaye wanda ya zo cikin ƙarfin 25 MG, 37.5 MG, 50 MG, 75 MG, da 100 MG. Metoprolol succinate, wanda aka sani da sunan mai suna Toprol XL, wani ƙaramin juzu'i ne na baka wanda ya zo cikin ƙarfin 25 MG, 50 MG, 100 MG, da 200 MG.
Dangantaka: Metoprolol da Atenolol
| Babban bambance-bambance tsakanin carvedilol da metoprolol | ||
|---|---|---|
| Carvedilol | Metoprolol | |
| Ajin magani | Beta-toshewa | Beta-toshewa |
| Alamar alama / ta kowa | Nau'i da nau'ikan sigar akwai | Nau'i da nau'ikan sigar akwai |
| Menene sunan alamar? | Coreg (sakin nan da nan) Coreg CR (ƙaddamarwa) | Lopressor (sakin nan da nan) Toprol XL (ƙaddamarwa) |
| Wani nau'i (s) ne miyagun ƙwayoyi ya shigo? | Rubutun baka | Rubutun baka |
| Menene daidaitaccen sashi? | Carvedilol (sakin nan da nan): 25 MG sau biyu a rana Carvedilol (tsawaitawa): 10 zuwa 80 MG sau ɗaya kowace rana Sashi ya dogara da yanayin da ake bi da shi | Metoprolol tartrate (fitarwa nan da nan): 50 zuwa 100 MG sau biyu a rana Metoprolol succinate (tsawaitawa): 25 zuwa 100 MG sau ɗaya kowace rana Sashi ya dogara da yanayin da ake bi da shi |
| Yaya tsawon maganin al'ada? | Dogon lokaci | Dogon lokaci |
| Wanene yawanci yake amfani da magani? | Manya | Manya |
Yanayin da carvedilol da metoprolol suka bi da shi
Dukkanin carvedilol da metoprolol succinate duk an amince dasu da FDA don magance matsalar rashin zuciya sakamakon ischemia, hauhawar jini, ko kuma cardiomyopathy. Dukansu beta-blockers kuma an yarda dasu don magance hauhawar jini.
Beta-blockers yawanci ana amfani dasu ban da sauran magunguna kamar su angiotensin-converting enzyme (ACE) masu hanawa da diuretics. Rage saukar jini ko siastalic na iya taimakawa rage haɗarin abin da ya shafi zuciya da jijiyoyin zuciya kamar ciwon zuciya ko bugun jini.
Ana iya amfani da Carvedilol da metoprolol don rage haɗarin cuta da mace-mace bin bugun zuciya . Hakanan waɗannan magunguna na iya magance rashin aiki na hagu na hagu bayan bugun zuciya.
Dukkanin magungunan za'a iya amfani dasu don magance angina pectoris, ko ciwon kirji, sanadiyyar cututtukan zuciya. Ana iya ba da umarnin Carvedilol ko metoprolol don rage hare-haren angina da haɓaka ƙarfin motsa jiki a cikin waɗanda ke fama da cututtukan zuciya ko gazawar zuciya.
Kashe-lakabin amfani da carvedilol da metoprolol sun hada da maganin arrhythmias, ko kuma bugun zuciya mara kyau, irin su fibrillation na atrial.
| Yanayi | Carvedilol | Metoprolol |
| Ajiyar zuciya | Ee | Ee |
| Hawan jini | Ee | Ee |
| Ciwon zuciya | Ee | Ee |
| Maganin angina | Kashe-lakabi | Ee |
| Arrhythmia | Kashe-lakabi | Kashe-lakabi |
Shin carvedilol ko metoprolol sun fi tasiri?
Da Carvedilol ko Metoprolol Gwajin Turai (COMET) wani gwaji ne wanda aka gwada shi wanda yayi kwatankwacin carvedilol da metoprolol a marasa lafiya masu fama da ciwon zuciya. An gudanar da gwajin a cikin kusan shekaru biyar a cikin fiye da marasa lafiya 1,500. Sakamakon, wanda aka buga a cikin Lancet , ya nuna yawan mutuwar 34% na carvedilol da 40% na metoprolol. A takaice dai, an sami carvedilol don ƙara rayuwa cikin marasa lafiya masu fama da ciwon zuciya fiye da metoprolol.
Nazarin kwatankwacin 2021 daga Jaridar American Cardiology ya gano cewa babu wani bambanci mai mahimmanci a cikin yanayin rayuwa bayan bugun zuciya tare da carvedilol da metoprolol a cikin marasa lafiya tare da ɓangaren fitarwa na hagu na sama da 40%. Koyaya, a cikin waɗanda ke da kashi huɗu na fitarwa na ƙasan ƙasa da kashi 40%, carvedilol na iya zama mafi ingancin beta-toshiyar.
A cewar wani meta-bincike , carvedilol da metoprolol suna kama da tasiri yayin amfani dasu bayan bugun zuciya. Idan aka kwatanta da placebo, an sami beta-blockers don rage abubuwan da suka shafi zuciya da bugun zuciya mai zuwa. Koyaya, ba a sami fa'idodi masu mahimmanci akan duk dalilin mutuwar ba, sake dubawa, da kuma asibiti don ko dai carvedilol ko metoprolol.
Dukansu carvedilol da metoprolol na iya zama zaɓuɓɓukan magani masu tasiri . Jiyya na iya zama na musamman bisa yanayin kulawa, yuwuwar illa, da tsada. Tuntuɓi mai ba da lafiya kan mafi kyawun magani a gare ku.
Verageaukar hoto da kwatancen farashin carvedilol vs. metoprolol
Carvedilol ya rufe mafi yawan Medicare da tsare-tsaren inshora. Biyan kuɗin zai dogara ne akan tsarin shirin da ɗaukar hoto. Matsakaicin farashin kuɗin carvedilol yana kusan $ 160. Ko da tare da inshora, carvedilol na iya tsada. Yin amfani da katin rangwame na SingleCare don carvedilol na iya iya rage kuɗin aljihu zuwa kusan $ 5.
Hakanan Metoprolol ya rufe ta yawancin Medicare da tsare-tsaren inshora. Tuntuɓi likitan magunguna ko shirin inshora don gano abin da biyan kuɗi na metoprolol zai kasance. Matsakaicin farashin kuɗi na metoprolol yana kusan $ 168. Katin rangwame na SingleCare don metoprolol tartrate ko metoprolol succinate na iya taimaka maka adana mahimmanci kan farashin takardar sayan magani.
| Carvedilol | Metoprolol | |
| Yawanci inshora ya rufe? | Ee | Ee |
| Yawanci an rufe shi ta Medicare Part D? | Ee | Ee |
| Yawan | 60 allunan (6.25 MG) | 60 allunan (25 MG) |
| Hanyar biyan kuɗaɗe na Medicare | $ 0 - $ 15 | $ 0– $ 65 |
| SingleCare kudin | $ 4 + | $ 4 + |
Sakamakon illa na yau da kullun na carvedilol vs. metoprolol
Carvedilol da metoprolol suna raba irin wannan tasirin. Illolin dake tattare da carvedilol sune rashi, gajiya, rauni, rashin karfin jini (hypotension), gudawa, yawan hawan jini (hyperglycemia), saurin bugun zuciya (bradycardia), da kuma karin kiba. Abubuwan da suka fi dacewa na yawan gajiya na metoprolol, jiri, zawo, ƙaiƙayi, da baƙin ciki.
M sakamako masu illa na carvedilol da metoprolol na iya faruwa, kamar halayen rashin lafiyan, haɗarin hawan jini, da kumburin hanji ko ƙarancin numfashi. Nemi agajin gaggawa idan kun sami mummunan kurji, kumburi, ko matsalar numfashi bayan shan carvedilol ko metoprolol.
| Carvedilol | Metoprolol | |||
| Sakamakon sakamako | Ana amfani? | Mitar lokaci | Ana amfani? | Mitar lokaci |
| Dizziness | Ee | 32% | Ee | 10% |
| Gajiya | Ee | 24% | Ee | 10% |
| Hawan jini | Ee | 9% | Ee | 1% |
| Gudawa | Ee | 12% | Ee | 5% |
| Hyperglycemia | Ee | 12% | Ee | * |
| Rashin ƙarfi | Ee | 7% | Ee | 10% |
| Sannu a hankali bugun zuciya | Ee | 9% | Ee | 3% |
| Karuwar nauyi | Ee | 10% | Ee | * |
| Rashin numfashi | Ee | * | Ee | 3% |
| Matsanancin sanyi | Ba | - | Ee | 1% |
| Bacin rai | Ee | <1% | Ee | 5% |
| Itching | Ee | <1% | Ee | 5% |
* ba'a ruwaito ba
Mitar ba ta dogara da bayanai daga gwajin kai-da-kai. Wannan na iya zama ba cikakken jerin illolin da zasu iya faruwa ba. Da fatan za a koma zuwa likitanku ko mai ba da sabis na kiwon lafiya don ƙarin koyo.
Source: DailyMed ( Carvedilol ,, DailyMed ( Metoprolol )
Magungunan ƙwayoyi na carvedilol vs. metoprolol
Dukansu carvedilol da metoprolol na iya rage saukar karfin jini da kuma saurin bugun zuciya. Sabili da haka, zasu iya hulɗa tare da wasu magunguna waɗanda ke da irin wannan tasirin. Dukansu carvedilol da metoprolol, kamar yawancin beta-blockers, na iya yin hulɗa tare da wakilai masu rage hawan jini, masu hana ƙwayoyin cuta na monoamine (MAOIs), da masu toshe tashar tashar. Shan waɗannan magunguna tare na iya ƙara haɗarin haɗarin hawan jini mai haɗari ko raunin zuciya.
Carvedilol da metoprolol yawanci ana sarrafa su a cikin hanta ta CYP2D6 enzyme. Magungunan da ke hana wannan enzyme na iya hulɗa tare da carvedilol da metoprolol, wanda zai iya haifar da ƙarin matakan carvedilol ko metoprolol. Levelsara matakan jini na carvedilol ko metoprolol na iya haifar da haɗarin tasirin illa.
Beta-blockers na iya kara tasirin rage karfin sukari-na magungunan hypoglycemic na baka kamar glipizide, metformin, ko insulin. Yakamata a yi hattara yayin da ake shan waɗannan magunguna tare.
Duba tebur da ke ƙasa don sauran hanyoyin hulɗa da ƙwayoyi masu yuwuwa.
| Drug | Ajin magani | Carvedilol | Metoprolol |
| Clonidine Guanethidine Reserpine | Ma'aikatan Alpha-adrenergic | Ee | Ee |
| Selegiline Isocarboxazid Phenelzine | Monoamine oxidase masu hanawa (MAOIs) | Ee | Ee |
| Amlodipine Nifedipine | Masu toshe tashar calcium | Ee | Ee |
| Fluvoxamine Fluoxetine Chlorpromazine Quinidine Ritonavir Terbinafine | Masu hana CYP2D6 | Ee | Ee |
| Glipizide Metformin Rosiglitazone Sitagliptin | Magungunan hypoglycemics | Ee | Ee |
| Dihydroergotamine Ergotamine | Ergot alkaloids | Ee | Ee |
| Hydralazine | Magungunan gyaran jiki | Ee | Ee |
| Digoxin | Carl glycosides | Ee | Ee |
| Cyclosporine | Immunosuppressants | Ee | Ee |
| Dipyridamole | Masu hana yaduwar platelet | Ee | Ee |
Tuntuɓi ƙwararren masanin kiwon lafiya don sauran hanyoyin hulɗa da ƙwayoyi
Gargadi na carvedilol da metoprolol
Kada a dakatar da masu hana Beta. Madadin haka, ya kamata a hankali a sanyaye su zuwa ƙananan allurai. Zai yiwu a sami ƙarin haɗarin mummunan cututtukan jijiyoyin jijiyoyin jini, angina, cututtukan zuciya, da kuma ciwon iska bayan da suka dakatar da beta-toshewar ba zato ba tsammani.
Beta-blockers na iya rufe alamun hypoglycemia ko hyperthyroidism , kamar saurin bugun zuciya. Marasa lafiya na ciwon sukari da waɗanda ke da matsalolin thyroid na iya buƙatar amfani da hankali tare da beta-blockers.
Dukansu carvedilol da metoprolol suna dauke da kashedin na bronchospasm, musamman ma wadanda ke fama da cutar huhu (COPD) ko wasu matsalolin numfashi. Koyaya, karatu sun nuna cewa masu hana beta-beta na iya rage haɓaka da haɓaka rayuwa a cikin waɗanda ke tare da COPD.
Faɗa wa mai kula da lafiyar ku idan kuna da tarihin rikicewar zuciya, asma, jinkirin bugun zuciya, matsalolin hanta, ko halayen rashin lafiyan abubuwan sinadarai a cikin carvedilol ko metoprolol. Tuntuɓi mai ba da kiwon lafiya don sauran gargaɗi da kiyayewa masu alaƙa da yin amfani da carvedilol ko metoprolol.
Tambayoyi akai-akai game da carvedilol vs. metoprolol
Menene carvedilol?
Carvedilol magani ne na beta-toshe wanda ake amfani dashi don magance matsalar zuciya da hauhawar jini. Hakanan za'a iya amfani dashi don haɓaka rayuwa bayan bugun zuciya. Carvedilol ya shigo cikin sifa nan da nan da kuma fadada-saki. An amince da FDA a 1995.
Menene metoprolol?
Metoprolol magani ne mai hana beta wanda zai iya magance raunin zuciya, hauhawar jini, da ciwon kirji mai ɗaci. Metoprolol succinate, sigar da aka fadada na metoprolol shima FDA ta amince dashi dan magance matsalar rashin zuciya. Sanarwa da sauri-metoprolol tana dauke da sinadarin metoprolol tartrate. Metoprolol an fara yarda da FDA a 1978.
Shin carvedilol da metoprolol iri daya ne?
Dukansu carvedilol da metoprolol sune masu toshe beta-adrenergic receptor blockers, ko beta-blockers. Dukansu ana amfani dasu don magance cututtukan zuciya da hauhawar jini. Koyaya, suna ƙunshe da abubuwa daban-daban masu aiki kuma suna aiki ta hanyoyi daban-daban. Carvedilol ba mai zaɓin beta-toshe bane kuma metoprolol shine beta-1 mai zaɓe beta-mai hanawa.
Shin carvedilol ko metoprolol ya fi kyau?
Carvedilol da metoprolol duka magunguna ne masu tasiri sosai idan aka kwatanta da placebo. Carvedilol na iya zama mafi kyau ga wasu marasa lafiya da ke fama da ciwon zuciya, a cewar COMET gwaji . Carvedilol da metoprolol suna da tasiri iri ɗaya don haɓaka rayuwa bayan bugun zuciya. Jagorori daga Kwalejin Kwalejin Zuciya ta Amurka (ACC) da Heartungiyar Zuciya ta Amurka (AHA) sun ba da shawarar yin amfani da ko dai carvedilol, metoprolol succinate, ko bisoprolol ga marasa lafiya da ke fama da ciwon zuciya tare da rage adadin fitarwa. Tuntuɓi mai ba da lafiya don mafi kyawun zaɓi na magani don yanayinku na musamman.
Shin zan iya amfani da carvedilol ko metoprolol yayin da nake da juna biyu?
Masu hana Beta suna amfani da a cikin mata masu ciki da yanayin zuciya. Koyaya, babu wata shaidar da ke nuna cewa beta-blockers suna da cikakkiyar lafiya ko cutarwa yayin ɗaukar ciki. Dukansu carvedilol da metoprolol na iya ɗaukar haɗarin cutar tayi. Tuntuɓi mai ba da lafiya don shawarwarin likita kafin amfani da beta-toshiya yayin ɗaukar ciki.
Zan iya amfani da carvedilol ko metoprolol tare da barasa?
Zai yiwu a sami haɗarin tasirin illa yayin haɗa beta-toshe tare da barasa. Shan carvedilol ko metoprolol tare da barasa na iya ƙara haɗarin bacci, jiri, da ƙaran jini. Hakanan giya na iya rage tasirin beta-blockers.
Shin carvedilol yana rage saukar karfin jini fiye da metoprolol?
Carvedilol na iya rage saukar karfin jini fiye da metoprolol. Wannan saboda carvedilol yana da kayan haɓaka wanda yake taimakawa shakatawar jijiyoyin jini da rage saukar karfin jini. Babu wani karatu da yayi kwatankwacin tasirin saukar jini na carvedilol da metoprolol. Koyaya, carvedilol na iya taimakawa hana abubuwan da suka shafi zuciya da jijiyoyin jini fiye da metoprolol a cikin marasa lafiya na hawan jini.
Za a iya canzawa daga metoprolol zuwa carvedilol? / Shin yana da lafiya don sauya beta blockers?
Yana da haɗari koyaushe canza beta-blockers idan an buƙata ko kamar yadda mai ba da sabis na kiwon lafiya ya ba da shawarar. Dogaro da beta-blocker, mai sauyawa zai iya kasancewa kai tsaye ko kuma za a iya yaye sashin farko na beta ɗin yayin da kashi na sabon beta-toshe ke ƙaruwa a hankali zuwa maƙasudin da ake so. Ana iya buƙatar ziyarar bibiyar don kimanta tasirin sabon beta-toshewar.
Menene kyakkyawan maye gurbin carvedilol?
Mafi kyawun maye gurbin carvedilol zai dogara ne akan yanayin da ake bi. Akwai magunguna biyu kawai FDA ta yarda da su don magance cututtukan zuciya banda carvedilol: bisoprolol da metoprolol succinate. Sauran misalan beta-blockers sun hada da atenolol, nebivolol, da propranolol.
Shin akwai mafi kyau beta toshewa fiye da metoprolol?
Abubuwan da za a iya maye gurbin metoprolol succinate don magance raunin zuciya sun haɗa da bisoprolol da carvedilol. Mafi kyawun toshe beta shine zaiyi muku aiki. Sauran dalilai na iya taka rawa wajen zaɓar mai toshe beta, kamar tsada, sakamako masu illa, da sauran magunguna da za ku iya sha.
