Atorvastatin vs. simvastatin: Bambanci, kamance, kuma wanne ne mafi alheri a gare ku
Magunguna vs. AbokiBayanin magunguna & manyan bambance-bambance | Yanayin da aka bi | Inganci | Inshorar inshora da kwatancen farashi | Sakamakon sakamako | Hadin magunguna | Gargadi | Tambayoyi
Atorvastatin da simvastatin wasu kwayoyi ne guda biyu da ake yawan ba da magani wanda ke kula da babban cholesterol. Likitanku na iya ba da umarnin ɗayan waɗannan magunguna idan kuna da babban ƙwayoyin LDL (ƙananan ƙarancin lipoprotein), wanda aka fi sani da mummunan cholesterol. Ta hanyar rage matakan cholesterol, atorvastatin ko simvastatin na iya taimakawa rage haɗarin bugun zuciya da bugun jini.
Musamman musamman, atorvastatin da simvastatin suna aiki azaman HMG-CoA reductase inhibitors. Ta hanawa HMG-CoA reductase enzyme, waɗannan statins rage samar da cholesterol a cikin hanta. Tare da ƙarancin cholesterol da ke yawo a cikin jini, jiki yana iya sake dawo da ƙwayar cholesterol da yawa da ƙananan matakan ƙwayar cholesterol.
Atorvastatin da simvastatin na iya aiki ta hanyoyi iri ɗaya amma suna da wasu bambance-bambance a cikin sashi, gudanarwa, da yiwuwar sakamako mai illa.
Menene manyan bambance-bambance tsakanin atorvastatin da simvastatin?
Atorvastatin kuma an san shi da sunansa, Lipitor, wanda aka amince da FDA a 1996. Daga cikin sauran amfani, an tsara shi don rage haɗarin kamuwa da zuciya ko bugun jini a cikin waɗanda ke tare da su cututtukan zuciya .
Atorvastatin (Menene Atorvastatin?) Yana da rabin rabi na awanni 14. Miyagun ƙwayoyi suna aiki sau ɗaya bayan an sha shi, kuma aikinsa na rage kiba zai iya wucewa 20 zuwa 30 hours bayan gudanarwa. Tare da rosuvastatin, ko Crestor, atorvastatin magani ne mai ƙarfi fiye da sauran ƙwayoyi kamar simvastatin da pravastatin.
Atorvastatin yana samuwa a cikin 10 MG, 20 MG, 40 MG, da kuma 80 MG Allunan. Abubuwan da aka fara farawa shine 10 ko 20 MG sau ɗaya a rana duk da cewa yawanci na yau da kullun na iya kaiwa daga 10 zuwa 80 MG sau ɗaya a rana. Ana iya ɗaukar Atorvastatin a kowane lokaci na rana.
Simvastatin (Menene Simvastatin?) Har ila yau, sanannen sanannen sunansa, Zocor. Idan aka kwatanta da atorvastatin, simvastatin wani tsohuwar magani ne wanda aka fara amincewa da FDA a 1991. Kamar sauran statins, ana amfani da shi don rage haɗarin bugun zuciya da shanyewar jiki a cikin waɗanda ke da haɗarin zuciya da jijiyoyin jini.
Kuna son mafi kyawun farashi akan simvastatin?
Yi rajista don faɗakarwar farashi na simvastatin kuma gano lokacin da farashin ya canza!
Sami faɗakarwar farashi
Ba kamar atorvastatin ba, simvastatin kayan aiki ne . Ma'ana, baya aiki har sai an canza shi, ko sarrafa shi, a cikin hanta. Bayan an sarrafa shi, simvastatin ya juye zuwa tsari mai aiki, simvastatin acid, wanda ke da rabin rai na kusan awa ɗaya zuwa biyu.
Ana samun Simvastatin cikin ƙarfin 5 MG, 10 MG, 20 MG, 40 MG, da 80 MG. Abubuwan da aka fara farawa shine 10 ko 20 MG sau ɗaya a rana, kuma yawan al'ada zai iya zama daga 5 zuwa 40 MG kowace rana. Ana ba da shawarar Simvastatin a ɗauka da daddare.
| Babban bambance-bambance tsakanin atorvastatin da simvastatin | ||
|---|---|---|
| Atorvastatin | Simvastatin | |
| Ajin magani | HMG-CoA mai hana hanawa Matsakaici | HMG-CoA mai hana hanawa Matsakaici |
| Alamar alama / ta kowa | Nau'in samfura da na yau da kullun akwai | Nau'in samfura da na yau da kullun akwai |
| Menene sunan alamar? | Lashin mai | Zocor |
| Wani nau'i (s) ne miyagun ƙwayoyi ya shigo? | Rubutun baka | Rubutun baka |
| Menene daidaitaccen sashi? | 10 zuwa 80 MG sau ɗaya a rana | 5 zuwa 40 MG sau ɗaya a rana |
| Yaya tsawon maganin al'ada? | Jiyya tare da atorvastatin na dogon lokaci ne don gudanar da matakan cholesterol da kiyaye ƙananan haɗarin kamuwa da zuciya da bugun jini. | Jiyya tare da simvastatin na dogon lokaci ne don sarrafa matakan cholesterol da kiyaye ƙananan haɗarin kamuwa da ciwon zuciya da shanyewar jiki. |
| Wanene yawanci yake amfani da magani? | Manya; yara da matasa masu shekaru 10 zuwa 17 da haihuwa tare da heterozygous familial hypercholesterolemia (HeFH) | Manya; yara da matasa masu shekaru 10 zuwa 17 da haihuwa tare da heterozygous familial hypercholesterolemia (HeFH) |
Yanayin da atorvastatin da simvastatin suka bi da shi
Ana amfani da Atorvastatin da simvastatin don dalilai iri ɗaya. Dukansu suna bi da matakan cholesterol mai yawa (hypercholesterolemia), matakan lipid mai girma (hyperlipoproteinemia), da matakan triglyceride mai girma (hypertriglyceridemia). A lokaci guda, statins na iya taimakawa haɓaka HDL cholesterol, wani nau'in kwalastaral mai kyau wanda ke da tasirin kariya daga cutar zuciya da jijiyoyin jini.
Atorvastatin da simvastatin kuma na iya rage haɗarin bugun zuciya da bugun jini a cikin masu zuwa:
- Manya ba tare da cututtukan zuciya ba (CHD) waɗanda ke da dalilai masu haɗari da yawa
- Manya da Ciwon sukari na 2 ba tare da CHD ba, amma waɗanda ke da dalilai masu haɗari da yawa
- Manya tare da cutar CHD
Abubuwan haɗari ga abubuwan da suka shafi zuciya da jijiyoyin jini na iya haɗawa da hawan jini (hauhawar jini) da hawan jini (ciwon sukari).
Atorvastatin da simvastatin na iya rage matakan cholesterol da na lipid a cikin waɗanda ke tare da su cututtukan kwayoyin lipid , kamar su homozygous familial hypercholesterolemia (HoFH). Waɗannan ƙa'idodin na iya magance yara da matasa (shekaru 10-17) tare da dangin dangi na hypercholesterolemia (HeFH).
Maganin atherosclerosis, ko kayan ajiyar mai a jikin bangon jijiyoyin jini, wani dalili ne yasa za'a iya bada umarnin atorvastatin ko simvastatin. Ta hanyar rage allo a jikin bangon jijiyoyin jini, wadannan tsaran zasu iya taimakawa rage alamomin kamar su ciwon kirji (angina).
| Yanayi | Atorvastatin | Simvastatin |
| Hypercholesterolemia | Ee | Ee |
| Hyperlipoproteinemia | Ee | Ee |
| Hyttriglyceridemia | Ee | Ee |
| Ciwon zuciya da rigakafin bugun jini | Ee | Ee |
| Atherosclerosis | Ee | Ee |
Shin atorvastatin ko simvastatin ya fi tasiri?
Atorvastatin da simvastatin duka magunguna masu tasiri ne. Karatun ya nuna cewa wadanda suke shan maganinsu na statin aƙalla 90% na lokaci suna da kasada 45% na mutuwa daga ciwon zuciya, bugun jini, ko kuma wani dalili. Gabaɗaya, statins suna da tasiri ƙwarai a rage matakan cholesterol da rage tasirin bugun zuciya da shanyewar jiki.
Babu wani gwaji mai karfi na kai-da-kai wanda ya kwatanta atorvastatin da simvastatin da aka gudanar. Koyaya, atorvastatin ana ɗaukarsa magani mafi ƙarfi fiye da simvastatin. A cikin recentayan binciken kwatancen kwanan nan , an gano atorvastatin ya zama mafi tasiri a rage LDL cholesterol (LDL-C) fiye da simvastatin. Wannan binciken ya tattara sakamako daga 50 bazuwar, gwaji na asibiti, da kuma kwatanta sauran magungunan statin kamar fluvastatin, pravastatin, rosuvastatin, da lovastatin. Rosuvastatin yana da iko mafi girma don rage matakan LDL a cikin binciken.
A daya nazari na yau da kullun , Nazarin daban-daban guda 75 da ke kwatanta magungunan statin an bincika. Dangane da sakamakon rukuni na nazari, yawan kwayar atorvastatin 10 MG na iya rage kwayar LDL ta 30% -40% yayin da kashi 10 na simvastatin 10 mg na iya rage kwayar LDL ta 20% -30%. Koyaya, sakamakon asibiti na wannan bambancin bazai zama mahimmanci ba.
Tuntuɓi mai ba da sabis na kiwon lafiya don ƙayyade mafi kyawun maganin ku. Amfanin statins zai dogara ne akan tarihin likita da na dangi, tsakanin sauran dalilai.
Verageaukar hoto da kwatancen farashi na atorvastatin vs. simvastatin?
Atorvastatin yana samuwa azaman magani na asali wanda kusan koyaushe ke rufe Medicare da sauran tsare-tsaren inshora. An tsara shi azaman kwaya ɗaya na yau da kullun wanda za'a iya bayar dashi a cikin samarwar kwana 30 ko 90-day. Matsakaicin farashin tsabar kuɗi na atorvastatin na iya zuwa $ 250. Koyaya, ana iya saukar da farashin zuwa $ 15 tare da takaddar SingleCare atorvastatin.
Hakanan ana samun Simvastatin azaman magani na gama gari. A matsayin ƙa'idar da aka saba amfani da ita, yawanci ana rufe simvastatin ta hanyar Medicare da tsare-tsaren inshora. Matsakaicin farashin sayar da simvastatin yana kusan $ 470. Koyaya, tare da katin ragi don simvastatin, kamar SingleCare, zaku iya tsammanin biya ƙasa da $ 10 don samarda kwana 30 na 20 mg Allunan a shagunan sayar da magani.
| Atorvastatin | Simvastatin | |
| Yawanci inshora ke rufe shi? | Ee | Ee |
| Yawanci an rufe shi ta Medicare Part D? | Ee | Ee |
| Daidaitaccen sashi | 10 MG sau ɗaya a rana (yawancin 30) | 20 MG sau ɗaya a rana (yawancin 30) |
| Hanyar biyan kuɗaɗe na Medicare | $ 0 - $ 16 | $ 0– $ 9 |
| SingleCare kudin | $ 15 + | $ 10 + |
Sami katin rangwame na kantin magani
Sakamakon illa na yau da kullun na atorvastatin vs. simvastatin?
Sakamakon illa na yau da kullun na statins, kamar atorvastatin da simvastatin, sun haɗa da matsalolin narkewar abinci kamar gudawa, rashin narkewar abinci, da tashin zuciya. Sauran illolin sun hada da jiri da kumburin hannu, kafafu, ko kafafu (edema). Statins na iya haifar da ciwon tsoka (myalgia) ko rauni na tsoka (myopathy).
Rashin haɗarin ciwon tsoka yana ƙaruwa tare da ƙananan ƙwayoyin statins. Koyaya, idan aka kwatanta da atorvastatin, ana daukar simvastatin yana da haɗarin myalgia mafi girma. Wasu mutane na iya samun wani jigilar kwayoyin halitta zuwa myalgia daga simvastatin. Kodayake duk statins suna da haɗarin haifar da ciwon tsoka a matsayin sakamako mai illa, FDA ya iyakance amfani na kwayar simvastatin 80 MG saboda ƙarin haɗari.
Sauran sakamako masu illa na yau da kullun ana iya samun su a cikin tebur ɗin da ke ƙasa.
| Atorvastatin | Simvastatin | |||
| Sakamakon sakamako | Ana amfani? | Mitar lokaci | Ana amfani? | Mitar lokaci |
| Hadin gwiwa | Ee | 7% | Ee | 0.1% |
| Gudawa | Ee | 7% | Ee | * |
| Maƙarƙashiya | Ba | - | Ee | kashi biyu |
| Rashin narkewar abinci | Ee | 5% | Ee | * |
| Ciwan | Ee | 4% | Ee | 6% |
| Ciwon tsoka | Ee | 4% | Ee | 4% |
| Cutar fitsari | Ee | 6% | Ee | 3% |
| Nasopharyngitis | Ee | 8% | Ba | - |
| Dizziness | Ee | * | Ee | 5% |
| Edema | Ee | * | Ee | 3% |
* ba'a ruwaito ba
Mitar ba ta dogara da bayanai daga gwajin kai-da-kai. Wannan na iya zama ba cikakken jerin tasirin illa bane wanda zai iya faruwa. Da fatan za a koma zuwa likitanku ko mai ba da sabis na kiwon lafiya don ƙarin koyo.
Source: DailyMed ( Atorvastatin ,, DailyMed ( Simvastatin )
Magungunan ƙwayoyi na atorvastatin vs. simvastatin
Atorvastatin da simvastatin ana sarrafa su da farko a cikin hanta ta hanyar CYP3A4 enzyme. Magungunan da ke hana, ko toshewa, wannan enzyme na iya haifar da ƙaruwar matakan atorvastatin ko simvastatin a cikin jini. Lokacin da aka ɗauka tare da mai hana CYP3A4 kamar clarithromycin ko itraconazole, atorvastatin na iya haifar da haɗarin ciwon tsoka (myalgia) ko rauni na tsoka (myopathy). Ruwan inabi kuma shine mai hana CYP3A4 wanda zai iya haɓaka matakan atorvastatin da simvastatin. A gefe guda, magunguna kamar rifampin da carbamazepine sune masu shigar da CYP3A4 waɗanda zasu iya rage matakan atorvastatin da simvastatin a cikin jiki.
Masu hana masu kare protein, kamar su ritonavir da lopinavir, na iya haifar da ƙarin matakan statins a cikin jiki. Matsayi mai girma a cikin jini na iya haifar da haɗarin mummunan sakamako, gami da myalgia. Hakanan magunguna masu ƙyama da niacin na iya ƙara haɗarin myalgia yayin ɗauka tare da atorvastatin ko simvastatin.
Shan atorvastatin tare da magungunan hana daukar ciki na iya haifar da karuwar matakan jini na maganin hana daukar ciki.
Shan rahotanni tare da warfarin an bayar da rahoton haifar da ƙarin matakan warfarin da haɗarin zub da jini. Koyaya, atorvastatin shine bazai yuwu ya tsoma baki ba tare da illar warfarin.
| Drug | Ajin magani | Atorvastatin | Simvastatin |
| Clarithromycin Erythromycin Itraconazole Ketoconazole Ruwan inabi | Masu hana CYP3A4 | Ee | Ee |
| Rifampin Carbamazepine | CYP3A4 masu ba da haske | Ee | Ee |
| Ritonavir Lopinavir Tsubirin Darunavir | Masu hana kariya | Ee | Ee |
| Gemfibrozil Fenofibrate | Fibrates | Ee | Ee |
| Niacin | Antihyperlipidemic | Ee | Ee |
| Digoxin | Cardiac glycoside | Ee | Ee |
| Norethindrone Ethinyl estradiol | Maganin hana haihuwa na baka | Ee | Ba |
| Warfarin | Anticoagulant | Ba | Ee |
Tuntuɓi ƙwararren masanin kiwon lafiya don sauran hanyoyin hulɗa da ƙwayoyi.
Gargadi na atorvastatin da simvastatin
Dukansu atorvastatin da simvastatin na iya haifar da mummunan lamura da suka shafi ciwon tsoka (myalgia) ko rauni na tsoka (myopathy). A cikin mawuyacin hali, waɗannan ƙwayoyin na iya haifar da rhabdomyolysis, ko saurin fashewar jijiyar ƙashi. Wani nau'ikan nau'ikan ƙwayar cuta, wanda ake kira myopathy necrotizing myopathy (IMNM) shima an ruwaito shi tare da amfani da yanayin.
Atorvastatin da simvastatin yawanci ana haɗuwa a cikin hanta. Sabili da haka, amfani da su na iya haifar da haɗari a cikin matakan enzyme na hanta. Ya kamata a kula da enzymes na hanta a duk cikin yanayin maganin statin. Hakanan ya kamata a kula da mutanen da ke da cutar hanta ko kauce wa laulayin gaba ɗaya.
Atorvastatin da simvastatin ya kamata a guji mata masu ciki da uwaye masu jinya. Wadannan statins na iya samun ƙarin haɗarin lahani na haihuwa.
Tambayoyi akai-akai game da atorvastatin vs. simvastatin?
Menene atorvastatin?
Atorvastatin, wanda aka fi sani da sunan mai suna Lipitor, magani ne mai cin abinci wanda ake amfani dashi don rage cholesterol da rage haɗarin bugun zuciya da shanyewar jiki. Tsarin al'ada na atorvastatin yana tsakanin 10 zuwa 80 MG kowace rana. Atorvastatin yana da tsawon rabin rai na awanni 14 kuma ana iya ɗauka a kowane lokaci na rana.
Menene simvastatin?
Simvastatin kuma sanannen sanannen sunan sa, Zocor. Yana da magani mai rikodin wanda zai iya rage matakan cholesterol, wanda, bi da bi, na iya taimakawa rage haɗarin bugun zuciya da shanyewar jiki. Matsakaicin adadin yawan kwayar simvastatin biyar zuwa 40 MG kowace rana. Simvastatin yana da ɗan gajeren rabin rayuwa kuma ana ba da shawarar a ɗauka da yamma.
Shin atorvastatin da simvastatin iri daya ne?
Atorvastatin da simvastatin duka suna cikin ajin magani wanda ake kira masu hana HMG-CoA reductase, ko statins. Dukansu ana amfani dasu don saukar da matakan LDL cholesterol. Koyaya, suna da wasu bambance-bambance a cikin wadatar ƙarfin da yadda ake ɗaukarsu.
Shin atorvastatin ko simvastatin shine mafi kyau?
Atorvastatin da simvastatin duka magunguna ne masu tasiri don rage ƙwayar cholesterol na jini. Koyaya, atorvastatin ana ɗaukarsa mafi ƙarfi mai ƙarfi. Atorvastatin ya daɗe a jiki kuma ana iya ɗauka da safe ko da daddare. Simvastatin yana da haɗarin ciwo na tsoka ko rauni fiye da atorvastatin, musamman a manyan allurai. Likitan da ke rubutawa zai tabbatar da mafi ingancin yanayin a kan kowane yanayi.
Shin zan iya amfani da atorvastatin ko simvastatin yayin da nake da juna biyu?
Kada ayi amfani da atorvastatin da simvastatin a lokacin daukar ciki. Matakan cholesterol na iya karuwa yayin daukar ciki kuma ya zama dole don tallafawa tayin da ke girma. Saboda haka, babu wata fa'ida ga shan waɗannan ƙwayoyin a lokacin daukar ciki. Hakanan suna iya haifar da cutar tayi a lokacin daukar ciki.
Zan iya amfani da atorvastatin ko simvastatin tare da barasa?
Bisa lafazin masana ilimin zuciya , yawan shan barasa a cikin tsakaita gabaɗaya yana da aminci tare da yin amfani da statin. Yawan shan giya wanda ya haifar da cutar hanta shine inda matsaloli zasu iya faruwa. Ya kamata a kula da enzymes na hanta a duk lokacin yin magani tare da wani yanayi.
Wane yanayi ne ke da karancin tasirin illolin?
Statins gaba ɗaya suna da aminci tare da ƙananan illa masu illa. Dangane da Heartungiyar Zuciya ta Amurka (AHA), fa'idodin statins ya fi ƙarfin haɗarin na sakamako masu illa. Koyaya, wasu statins, kamar su pravastatin da fluvastatin , na iya samun ƙananan haɗarin myalgia fiye da simvastatin da atorvastatin. Idan aka kwatanta da statins da aka bayar a ƙananan allurai, ƙananan ƙwayoyin cuta na iya haifar da sakamako masu illa. Misali, kashi 80 na simvastatin yana da mafi girman haɗarin haifar da myalgia. Saboda wannan dalili, FDA ta iyakance wannan kwayar simvastatin ga wasu mutane kawai.
Menene sakamakon illa na atorvastatin?
Hanyoyi masu illa na dogon lokaci na maganin statin na iya bambanta dangane da mutum. Dogon lokaci sakamako masu illa na statins na iya haɗawa da ciwon tsoka, lalacewar hanta, ƙara yawan sukarin jini, da matsaloli tare da ƙwaƙwalwa. Koyaya, haɗarin cututtukan sakamako na dogon lokaci ana ɗauka mara ƙasa lokacin da aka tsara magungunan kuma aka gudanar dasu yadda yakamata.
Shin atorvastatin yana da illa ga koda?
Yawan atorvastatin baya buƙatar daidaitawa cikin waɗanda ke da matsalar koda. A wasu mutane da ke fama da matsalolin koda mai yawa, yin amfani da atorvastatin na iya buƙatar sa ido.
Gabaɗaya, atorvastatin baya da haɗari ga kodan. Koyaya, yin amfani da atorvastatin na iya haifar da haɗarin kamuwa da rhabdomyolysis, wanda hakan zai iya haifar da rashin saurin koda a cikin mawuyacin yanayi. Yi magana da likitanka idan kana da tarihin matsalolin koda kafin ka fara akan maganin statin.
