Menene finasteride kuma menene ake amfani dashi?

Bayanin Magunguna

Menene narkar da yanayin namiji da kara girman prostate suke da shi? Dukansu ana bi da su tare da finasteride-kuma a nan ne kamannensu ya ƙare. Menene? Wannan jagorar yana bayanin yanayin da yake kulawa da shi, illolin da ke tattare da shi, da sauran hanyoyin magance su.

Menene finasteride?

Finasteride shine mai hanawa 5-alpha reductase. Yana aiki ta hanyar toshe samarwar 5-alpha reductase enzyme, wanda ke canza testosterone zuwa dihydrotestosterone (DHT), yana haɓaka haɓakar prostate da haifar da asarar gashi. Tasirin DHT na gari ne, ma'ana kasancewar sa a fatar kai ba ya nuna faɗaɗa prostate da akasin haka. Kodayake, finasteride, a ƙarƙashin sunaye daban-daban da kuma allurai daban-daban, yana da tasiri wajen magance duka yanayin. Sunayen sunaye na finasteride sun hada da Proscar (na kara girman prostate) da Propecia (na asarar gashi). Wannan magani na iya rage haɗarin ƙananan ƙwayar cutar kanjamau.

Me ake amfani da finasteride?

Hukumar Abinci da Magunguna (FDA) ta amince da finasteride don maganin hyperplasia mai saurin ciwo (BPH) da androgenetic alopecia, rage sirrin gashi a hankali. Tambayi mai ba da sabis na kiwon lafiya game da sauran abubuwan amfani da lakabin waje.

Ignananan hyperplasia

Sunan alama Proscar za a iya amfani da shi shi kaɗai ko a hade tare da Cardura (doxazosin) don magance BPH, faɗaɗa glandan prostate. Idan glandon prostate yayi girma, sai ya dannata kan fitsarin. Kwayar cutar BPH, a cewar Gidauniyar Kula da Urology , hada da:

• Rike fitsari –ya kasa yin komai a mafitsara
• Jin saurin yin fitsari
• Samun ragowar kwararar fitsari
• Matsalar fitsari
• Ana buƙatar damuwa don yin fitsari

Nazarin ya nuna cewa mutanen da ke shan finasteride na tsawon watanni 12 an lura cewa suna da ragin kashi 23% na masu hanawa da kuma rage kashi 18% a cikin wadanda ba su da matsala, karuwar fitsari, da kuma raguwar kashi 19 cikin 100 a matsakaiciyar matsakaiciyar cuta. Douglas P. Jeffrey , MD, likitan iyali a Oregon kuma mai ba da shawara kan kiwon lafiya don Kiwan lafiya .Yana da mahimmanci a dauki finasteride na tsawon watanni shida zuwa 12 kafin a rage girman prostate sosai don inganta alamun da ke tattare da BPH. Alamomin sun sami sauki muddin aka ci gaba da shan magani tsawon shekaru. Da zarar an dakatar da maganin asalin alamun BPH gabaɗaya zasu dawo. Magungunan ana ɗaukarsu amintattu don amfanin dogon lokaci.

Wannan haɗarin ga wannan yanayin yana ƙaruwa ne da shekaru. Rabin dukkannin maza tsakanin shekara 51, da 60% zuwa 90% na waɗanda suka girmi shekaru 80 suna fuskantar alamomin da haɓakar prostate ke haifarwa, a cewar Cibiyar Nazarin Ciwon Suga ta Duniya da Ciwan Narkar Da Koda (NIDDK). Finasteride na iya sarrafa BPH, amma ba ya warkar da shi. Ga wasu mutane, yana rage buƙata tiyata.

Namijin kwalliyar maza

Propecia na iya magance cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan androgenetic alopecia-ƙarancin namiji. Wannan magani shine ƙananan ƙwayar finasteride fiye da Proscar. Yana taimakawa inganta layin gashi da zubewar gashi a saman fatar kan mutum. Koyaya, baya taimakawa siririn gashi a wurin ibada, a cewar Lissafi Plusari .

Propecia tana jinkirin asarar gashi kuma tana iya taimakawa ga sabon haɓakar gashi, a cewar Kaiser Dindindin . Mutane da yawa ba sa ganin ci gaba har tsawon watanni uku zuwa shida bayan fara shan magani, kuma yana aiki ne kawai idan ka ci gaba da shan shi. Idan ka daina, sabon ci gaban ka gashi zai fadi cikin watanni shida zuwa 12 da ka daina.

Finasteride ya fi tasiri fiye da magunguna na yau da kullun don asarar gashin namiji, a cewar Dr. Jeffrey. Wasu nazarin suna bayar da rahoton cewa maza sun sami mahimmancin haɓakar gashi bayan amfani da shekaru biyu tare da mahimmancin ci gaba ga samari tsakanin shekarun 18 zuwa 41.

Wani lokaci ana amfani da Finasteride don bi da wasu sharuɗɗa a kashe-lakabin. Kashe-lakabin yana nufin cewa FDA ba ta yarda da magani don kula da yanayin ba; Koyaya, bayanan shaida sun nuna yana iya taimakawa. Wasu daga cikin waɗannan sharuɗɗan sun haɗa da:

Hirsutism

Wannan yanayin yana haifar da yawan ci gaban gashi ga mata. Girman gashi yana bayyana a sassan jiki inda gashi baya yawanci girma, kamar a saman leɓe, ƙugu, kirji, ciki, da baya. Tsakanin 5% da 10% na mata suna da hirsutism, a cewar Asibitin Cleveland . Abubuwan da ke haifar da cutar sun hada da cututtukan ƙwayoyin cuta na polycystic (PCOS), menopause, wasu magunguna, da sauran yanayin kiwon lafiya wanda yawan kwayar testosterone ke haifarwa.

Maganin transgender hormone (namiji zuwa mace)

Finasteride wani lokaci yana da amfani a cikin maganin hormone don matan transgender don rage haɓakar gashi a sassan jiki banda kai.

Rigakafin cutar kansar mafitsara

Finasteride na iya rage haɗarin ƙananan ƙwayar cutar kanjamau. Wani babban binciken da aka gudanar ya gano cewa finasteride yana rage haɗarin kamuwa da cutar sankara ta maza a cikin shekaru 55 zuwa sama, a cewar Cibiyar Cancer ta Kasa . Wannan binciken ya nuna cewa duk da cewa maganin na rage kasadar kamuwa da cutar kansar mafitsara, amma hakan na kara barazanar gano cutar kansar mafitsara mai girma, wacce tafi karfi da kuma wuyar magani. Koyaya, a binciken da aka yi kwanan nan , wanda ya biyo bayan maza suna shan finasteride na shekaru 20, ba su sami ƙaruwar mace-macen da ke da alaƙa da cutar sankara ba.

Dokta Howard Parnes, ɗaya daga cikin marubutan binciken, ya yi imanin cewa sakamakon farko da ke nuna karuwar cutar sankara mai saurin sauƙaƙawa, aƙalla a wani ɓangare, ta hanyar ingantaccen bincike saboda abubuwan da ke haifar da ƙwayoyi. Rage girman glandan prostate ya kara yiwuwar samun samfuran tabbatacce akan biopsy don ganewar asali, kuma finasteride da alama yana inganta ƙwarewar gwajin PSA don gano cutar kanjamau mai girma.

FDA ba ta amince da finasteride don rigakafin cutar kansa ba.

Finasteride allurai

Ana samun Finasteride a cikin mg 1 da 5 mg, a cewar Bayanin Desk na Likita ( PDR ). Abubuwan da aka saba da su don yanayi daban-daban sune:

• BPH: 5 MG kowace rana, ana ɗauka tare ko ba abinci, na mafi ƙarancin watanni shida, har zuwa watanni 12 idan ya cancanta. Yi amfani dashi shi kadai ko a hade tare da Cardura (doxazosin).
• Tsarin namiji asarar gashi: 1 MG kowace rana don mafi ƙarancin watanni uku. Ya kamata ku lura da ci gaba a tsakanin watanni 12. Idan babu ci gaba, ƙarin magani mai yiwuwa ba zai yi tasiri ba. Dole ne ku ci gaba da amfani don kiyaye fa'idodin maganin.
• Hirsutism a cikin mata: 5 mg kowace rana, ko dai shi kaɗai ko a hade tare da maganin hana haihuwa.
• Maganin transgender hormone: 1 zuwa 5 MG kowace rana, a cewar Katie Imborek , MD, a co-darektan Jami'ar Iowa ta LGBTQ Clinic.

Menene sakamakon illa na finasteride?

Kamar yadda yake tare da duk magunguna, finasteride na iya haifar da illa. Ba kowa ne ke fuskantar mummunan tasiri ba; Koyaya, ya kamata ku kasance da masaniya game da yuwuwar sakamako mai illa na finasteride, wanda zai haɗa da lalatawar jima'i. A cewar PDR , sakamako masu illa na kowa sun haɗa da:

• Cutar rashin karfin jiki
• Rage sha'awar sha'awa
• Matsaloli tare da inzali, gami da rage saurin inzali
• Jin zafi a cikin jijiyoyin
• Bacin rai

Effectsarin sakamako mai tsanani, gami da halin rashin lafiyan, sune:

• Rash
• Itching
• Kyauta
• Kumburin lebe da fuska
• Wahalar numfashi ko haɗiyewa

Idan kun fuskanci wani mummunan sakamako mai illa, ya kamata ku tuntuɓi likitanku ko ku nemi shawarar likita nan da nan.

Finasteride na iya ƙara yawan haɗarin kamuwa da cutar sankarar mama, a cewar Jami'ar Michigan . Ya kamata ku tuntubi ƙwararren likita idan kun lura:

• Kullun nono
• Ciwon nono ko taushi
• Fitowar nono
• Sauran canjin nono

Duk da yiwuwar illa, finasteride shineamintacce cikin amfani don inganta haɓakar gashi ga wani yanki na samari. Bai kamata ayi amfani dashi ba tare da tattaunawa ba. Bincike mai kyau game da yiwuwar gajeren lokaci da na dogon lokaci da fahimtar cewa asarar haɓakawa watanni tara zuwa 12 bayan dakatar da finasteride suna da mahimmanci a sake dubawa kafin farawa, in ji Dokta Jeffrey. Tunda finasteride yana da halin rage matakan PSA yana buƙatar PSA a kula dashi kuma a sami gwajin dubura na zamani (DRE) na lokaci zuwa duba prostate. Akwai yuwuwar yin ruɓaɓɓen ciwon sankara ta hanyar rage PSA. DRE ya kamata a yi kafin farkon fara magani kuma a cikin watanni shida bayan farawa. DRE shekara ta zama mai mahimmanci.

Gargadin Finasteride

Wasu maza suna fuskantar cututtukan post-finasteride (PFS) lokacin da suka daina shan magani. PFS ya hada da ci gaba da jima'i, ilimin jijiyoyin jiki, na zahiri, da kuma illa masu tasiri.Ciwon bayan-finasteride ba shi da cikakken bayani kuma yana wakiltar cuta mai rikitarwa. Yana haɗuwa da rukuni na alamun jima'i, na zahiri, da na halayyar mutum wanda ke haɓaka yayin ko bayan finasteride yana farawa kuma yana iya ci gaba bayan dakatarwa. Kwayar cututtukan sun hada da raguwar libido, ED, da kuma matsalar saurin fitar maniyyi da kuma bacin rai, a cewar Dr. Jeffrey. A wasu lokuta, alamun cutar sun ɓace a kan lokaci duk da cewa a wasu sun daɗe na shekaru da yawa.

Babu warkewa kuma kaɗan, idan akwai, jiyya, bisa ga Gidauniyar PFS .Gidauniyar ta nuna cewa an samu rahotanni 16,198 na mummunar magani game da magani a duk duniya, sanannun masu kisan kai 63, da ƙasashe 23 waɗanda ke ba da gargaɗi game da maganin. Suna aiki tuƙuru don cire miyagun ƙwayoyi daga kasuwa, ko kuma, aƙalla, don samun gargaɗi mai ƙarfi da aka buga a kan duk takardun magani da takaddun bayanan haƙuri.

Kodayake an danganta finasteride da raguwar ƙananan ƙwayar ƙwayar ƙwayar ƙwayar cuta, Nazarin 2003 gano shi na iya kara yawan kasadar kamuwa da cutar kansar mafitsara mai girma, wacce ita ce mafi saurin kamuwa da cutar sankara. Karatun da ke gaba, kamar wanda aka buga a Binciken Rigakafin Ciwon kansa , a ƙarshe ba a sami karuwar ƙididdigar ƙididdiga ba a cikin manyan masu fama da cutar ƙwanƙwasa a cikin waɗanda ke shan finasteride.

Matan da ke da ciki ko kuma suna iya yin ciki kada su taɓa allunan finasteride saboda wannan magani na iya haifar da lahani na haihuwa.

Shin akwai wasu hanyoyi zuwa finasteride?

Madadin zuwa finasteride ya dogara da dalilin da yasa kuka sha magani.

Avodart (dutasteride) don BPH

Avodart wani nau'in hadadden 4-azasteroid ne wanda yake kula da BPH. Yana aiki ta hanyar hana juyawar testosterone zuwadihydrotestosterone (DHT), wanda ke inganta kwararar fitsari kuma zai iya rage bukatar yin tiyata. Yi amfani dashi shi kaɗai ko tare da magani Flomax (tamsulosin).

Alpha-masu toshewa don BPH

Alpha-blockers suna aiki ta hanyar shakatawa tsokoki a cikin mafitsara da prostate kuma suna taimakawa kusan 70% na maza da BPH, a cewar Kiwon Lafiya na Harvard . Waɗannan suna farawa aiki a cikin kusan mako ɗaya zuwa biyu kuma suna da ƙananan sakamako masu illa. Alpha-blockers sun hada da:

• Rapaflo (silodosin)
• Flomax (tamsulosin)
• Tashin hankali (alfuzosin)

Ba su da wani tasiri kan damar kamuwa da cutar sankara ta prostate.

Madadin maza don kwalliyar maza

Baya ga finasteride, magani na kan-kan-kan-counter na iya magance baƙon namiji. Rogaine (minoxidil) yana samuwa azaman ruwa ko kumfa, ana shafawa a fatar kai a kullum, a cewar Asibitin Mayo . Zai iya daukar akalla watanni shida kafin ka fara lura da karin asara da sabon ci gaban gashi. Maganin yana aiki kawai yayin amfani da shi. Lokacin da kuka tsaya, duk wani sabon ci gaban gashi zai iya rasa.

Magungunan marasa magani sun haɗa da tiyatar dasa gashi, ko tiyatar gyarawa, da kuma na’urar amfani da laser. Kuna iya buƙatar aiki fiye da ɗaya, kuma inshora yawanci baya ɗaukar waɗannan jiyya.