Tasirin illar Jardiance da yadda za'a guje su

Bayanin Magunguna

Jardiance sakamako masu illa | Rage nauyi | Tashin hankali | Gangrene | Har yaushe tasirin sakamako zai wuce? | Gargadi | Abubuwan hulɗa | Yadda ake kauce wa illolin

Jardiance (sashi mai aiki: empagliflozin) magani ne mai suna wanda ake amfani da shi wanda, tare da abinci da motsa jiki, yana taimakawa rage sukarin jini cikin marasa lafiya da Type 2 ciwon sukari da kuma rage haɗarin mutuwar zuciya da jijiyoyin jini a cikin marasa lafiya da ke dauke da ciwon sukari na Type 2 da cutar ta zuciya. Empagliflozin na aiki ta hanyar kara kodar ‘cire glucose daga jini zuwa cikin fitsari. Jardiance yana da tasiri da yawa akan jiki kuma bazai dace da kowa ba. Fahimtar illolin, faɗakarwa, da ma'amala da ƙwayoyi zai taimaka wa marasa lafiya daidaita fa'idodi da illolin shan Jardiance.

Dangantaka: Learnara koyo game da Jardiance | Samu rangwamen Jardiance

Sakamakon illa na yau da kullun na Jardiance

Kamar yadda yake tare da duk magungunan magani, Jardiance yana haifar da sakamako masu illa da yawa. Jardiance, kodayake, galibi za a sanya shi azaman magani na biyu a haɗe tare da sauran magungunan ciwon sukari kamar su metformin. Hanyoyi masu illa, to, na iya bambanta tsakanin marasa lafiya. Abubuwan da suka fi dacewa na yau da kullun, gogaggen by fiye da 5% na marasa lafiya, sune cututtukan fitsari da cututtukan fungal na farji ko azzakari.

Sakamakon illa na yau da kullun na Jardiance sun haɗa da:

• Cututtukan fitsari
• Tsarin al'aura ko cututtukan yisti
• Babban cututtuka na numfashi
• Yawan fitsari
• Matsakaicin matakan mai ko kitse a cikin jini
• Hadin gwiwa
• Tashin zuciya da
• Matsalar koda

Kadan akasari, Jardiance na iya rage girman jini kuma yana haifar da rashin ruwa da ƙananan karfin jini.

Babban tasirin tasirin Jardiance

Mafi munin illa na Jardiance sun haɗa da:

• Pressureananan hawan jini
• Sugararancin sukarin jini
• Ketoacidosis
• Mutuwar koda ko rauni
• Ciwon ƙwayar fitsari mai tsanani (urosepsis)
• Koda kamuwa da cuta (pyelonephritis)
• Gangrene (necrotizing fasciitis na perineum)
• Raunin rashin lafiyan mai tsanani da haɗari kamar angioedema ko halayen fata mai tsanani

Ketoacidosis, mummunan sakamako na magungunan ciwon sukari, yana faruwa lokacin da ketones suka haɗu a cikin jini sakamakon jiki ta amfani da kitse don mai. Ketoacidosis yana da haɗarin gaggawa na gaggawa na likita kuma yana da alamun bayyanar cututtuka kamar ƙishirwa mai tsanani, yawan fitsari, tashin zuciya, ciwon ciki, rauni, gajiya, da ƙarancin numfashi. Saboda ƙarin haɗari ga ketoacidosis ko ƙarancin sukarin jini, yakamata a bincika matakan ketone da glucose a kai a kai yayin ɗaukar Jardiance.

Rashin nauyi mai nauyi

Baya ga sarrafa matakan sukarin jini, an nuna Jardiance yana rage duka nauyi da rarraba kitse na jiki . Musamman, Jardiance yana rage ƙimar ciki (ƙwayar visceral adiposity ko VAT). Kitsen jiki na ciki yana haifar da haɗarin bugun zuciya, bugun jini, da sauran abubuwan da suka shafi zuciya da jijiyoyin jini. Duk wani ragi a cikin kitse yana taimakawa rage haɗarin mutuwa daga cututtukan zuciya ko wasu yanayi na zuciya da jijiyoyin jini.

Tashin hankali na Jardiance

Jardiance baya shafar tsarin juyayi. Koyaya, idan aka sha tare da wasu magungunan ciwon sikari, Jardiance na iya haifar da sukarin jini ya faɗi zuwa ƙananan matakan haɗari. Wanda ake kira hypoglycemia, karancin sukari a cikin jini yana sanya jiki sakin epinephrine, wanda aka fi sani da adrenaline. Yawancin alamomin cutar sukari a cikin jini suna faruwa ne ta wannan saurin adrenaline: damuwa, bugun zuciya da sauri, bugun zuciya, jiti, zufa, rawar jiki, da kuma damuwa. Idan shan Jardiance yana haifar da damuwa ko wasu alamomi na sukarin jini, dauki madaidaicin tushen sukari kamar ruwan 'ya'yan itace kuma nemi likita cikin gaggawa. Mai ba da sabis na kiwon lafiya na iya ba da umarnin kayan aikin gaggawa na glucagon idan ƙarancin sukarin jini abu ne na yau da kullun.

Jardiance gangrene

Gaba ɗaya, marasa lafiya da ciwon sukari sun fi saurin kamuwa da ƙwayoyin cuta da fungal. Wannan saboda kwayoyin cuta da naman gwari suna cinye glucose don kuzari. Hawan jini mai yawa yana kara wadatar abincinsu. Hawan jini mai yawa yana rage ikon garkuwar jiki don yakar cutuka.

Jardiance yana rage matakan glucose na jini ta hanyar tace glucose daga cikin jini zuwa cikin fitsari. Wannan yana rage suga cikin jini - wanda abu ne mai kyau-amma yana sanya fitsari ya zama sikari. Kwayar cuta, yisti, da kuma narkewa a cikin hanyoyin fitsari da al'aurarsu suna bunƙasa a cikin wannan yanayin mai cike da sikari. Sakamakon haka, koda, sashin fitsari, da cututtukan al'aura sune sakamako mai illa na Jardiance.

A cikin al'amuran da ba safai ba, cututtukan ƙwayoyin cuta da Jardiance ya haifar na iya ƙarewa tare da haifar da cututtuka masu tsanani kamar:

• Urosepsis (yawan kwayar cuta a cikin sashin fitsari)
• Pyelonephritis (cututtukan koda mai tsanani)
• Gangaran Fournier

Gangaran Fournier sakamako yayin da kwayar cuta ta kwayar cuta ta fashe daga karfi kuma ta fara kai hari da kashe kyallen takarda a fatar da ke kusa da al'aura da dubura. Saboda yanayi ne mai matukar hatsarin rai idan ba a kula da shi ba, ya kamata ka nemi likita cikin gaggawa idan kana shan Jardiance kuma ka lura da alamomin cutar ta Fournier's gangrene kamar:

• Zazzaɓi
• Jin rashin lafiya
• Matsakaici zuwa mai tsananin kumburi da zafi a al'aura ko kusa da dubura
• Wari mara kyau a yankin da abin ya shafa
• Fashewa, cushewa, ko sautin sauti lokacin da kake shafa yankin

Kwayar cututtukan daji na Fournier na iya farawa a cikin makon farko na shan Jardiance.

Har yaushe tasirin tasirin Jardiance zai wuce?

Sakamakon illa na yau da kullun na Jardiance na iya magance tsawon lokacin da aka sha maganin. Jardiance yawanci yana fita daga jiki a cikin fewan kwanaki (rabin rai na 12 awanni, don haka mafi yawan kwayoyi ana share su a cikin awanni 24, amma yana ɗaukar kwanaki da yawa don ya share jikin gaba ɗaya), don haka duk wani ƙananan sakamako masu illa kamar ƙara fitsari ya kamata yayi rauni tsakanin kwana ɗaya ko biyu bayan an daina amfani da miyagun ƙwayoyi. Koyaya, cututtuka, rashin lafiyar hanta, da raunin koda na iya ɗaukar kwanaki ko makonni don warwarewa.

Kuskuren jardiance & gargadi

Jardiance ba shine madaidaicin magani ga kowa ba. Saboda yana aiki ta hanyar karawa kodar tacewar suga, bai dace da marasa lafiya masu cutar koda mai tsanani ko ta karshe ko kuma wadanda ke aikin wankin koda ba. Hakanan bai kamata a ba kowa wanda yake da sananniyar lamuran ga empagliflozin, sinadarin aiki a Jardiance. Bugu da ƙari, mutanen da ke fama da ciwon sukari ba su da kyau 'yan takara don maganin Jardiance. Ba a amfani da Jardiance a cikin marasa lafiya da ke dauke da ciwon Suga na 1.

Jardiance ya zo tare da gargaɗi da yawa, gami da:

• Rashin yiwuwar haifar da hauhawar jini a cikin tsofaffi da marasa lafiya tare da larurar koda, ƙananan jini, ko waɗanda ke shan diuretics (kwayoyi na ruwa)
• Bukatar saka idanu kan marasa lafiya don alamun
  • Ketoacidosis
  • Rashin koda ko rauni
  • Tsananin cututtukan fitsari
  • Gangaran Fournier
  • Cututtukan fungal na al'aura
  • Sugararancin sukarin jini da
  • Inara yawan matakan cholesterol mara kyau (LDL)

Tsoffin marasa lafiya

Marasa lafiya sama da 65 na iya fuskantar illa kamar rashin karfin jini, rashin ruwa a jiki, ko matsalolin koda.

Yara

FDA bai amince da Jardiance ba don amfani a cikin yara ƙanana 18.

Rashin nakasa

Marasa lafiya tare da rage aikin koda suna cikin haɗarin haɗarin cutar koda ko rauni na koda.

Ciki da shayarwa

Gabaɗaya, Jardiance yana da karfin gwiwa don amfani da mata masu ciki a kowane watanni uku amma an hana shi a cikin watanni na uku da na uku. Koyaya, akwai ƙaramin bincike wanda ke alakanta amfani da Jardiance yayin ɗaukar ciki zuwa lahani na haihuwa ko ɓarin ciki.

Duk da yake babu wani karatu da ke nuna yadda Jardiance yake a cikin ruwan nono, bai kamata uwaye masu shayarwa su sha Jardiance ba. Akwai yiwuwar cewa koda adadi kaɗan na iya lalata ci gaban ƙodar jaririn da ke shayarwa.

Hadin gwiwar Jardiance

Jardiance yana da mahimmancin ma'amala a asibiti tare da ƙwayoyi da yawa. Da yawa suna lalata ikon jiki don kawar da Jardiance. Waɗannan ƙwayoyi suna haɓaka fa'idar magani ta Jardiance amma kuma suna haɓaka haɗari da ƙarancin sakamako masu illa. Ya kamata a guji wasu magunguna, kamar su diuretics, insulin, da kwayoyi kwatankwacin Jardiance yayin shan Jardiance.

Masu hana SGLT2

Jardiance na dangin kwayoyi ne da ake kira masu hana kawancen sodium-glucose co-transporter 2 (SGLT2). Wadannan kwayoyi suna aiki ta hanyar rufe wani inji a cikin kodan wanda ke dawo da glucose daga fitsari zuwa cikin jini. Sakamakon haka, marasa lafiya akan Jardiance suna ficewa ko'ina Kara gram 64 zuwa 78 a rana ya danganta da maganin da aka tsara. Don kaucewa saukowar haɗari cikin sukarin jini, kada a ɗauki Jardiance tare da sauran masu hana SGLT2:

• Farxiga (dapagliflozin)
• Invokana (canagliflozin)
• Steglatro (ertugliflozin)

Diuretics

Diuretics (kwayoyin kwayoyi) suna kara yawan ruwa da wutan lantarki da ake fitarwa a cikin fitsarin. An tsara su yawanci don yanayin likita daban-daban, galibi galibi hawan jini da kumburi saboda ajiyar ruwa. Jardiance na iya mu'amala da masu yin fitsari kuma yana haifar da fitsari sama da na al'ada, wanda ke haifar da rashin ruwa a jiki da ƙarancin jini, wanda kan haifar da hauhawar jini. Mai ba da sabis na kiwon lafiya na iya zaɓar wasu hanyoyin kwantar da hankali, rage kwayar cutar, ko sa ido kan mai haƙuri a hankali.

Insulin da insulin magunguna masu motsawa

Insulin da magungunan da ke ƙara yawan samar da insulin na jiki (insulin secretagogues) suna ƙara haɗarin ƙarancin sukarin jini lokacin da aka ɗauke su da Jardiance. Far zai buƙaci gwajin sukarin jini akai-akai, kuma ƙwanan insulin na iya buƙatar saukowa.

Wasu masu koyar da insulin galibi an tsara su azaman magani na farko tare da Jardiance. Wadannan sun hada da glipizide, glyburide, da glimepiride. Sauran magunguna kamar nateglinide da repaglinide suma suna sanya jiki fitar da ƙarin insulin. Ana buƙatar bincikar sukarin jini koyaushe yayin haɗa Jardiance da ɗayan waɗannan magunguna.

Sauran magunguna

Aƙarshe, wasu magungunan suna haɓaka ko rage tasirin Jardiance akan sukarin jini. Magungunan da ke ƙaruwa ko haɓaka tasirin warkewar Jardiance suma suna sanya mutane cikin haɗari don ƙarancin sukarin jini. Wadannan sun hada da:

• Magungunan ciwon suga kamar metformin, pioglitazone, da acarbose
• Zaɓuɓɓukan maganin serotonin reuptake (SSRIs) kamar su Prozac (fluoxetine) ko Paxil (paroxetine)
• Monoamine oxidase masu hanawa (MAOIs) kamar su Marplan (isocarboxazid), Nardil (phenelzine), ko linezolid
• Quinolone maganin rigakafi kamar ciprofloxacin ko levofloxacin
• Salisu kamar su asfirin, ibuprofen, ko diclofenac
• Barbiturates kamar butalbital ko kwanciya
• Bronchodilators kamar doxofylline

A gefe guda, corticosteroidskamar dexamethasone, budesonide, da hydrocortisone suna ƙara haɗarin babba sukarin jini lokacin da aka sha shi da Jardiance.

Haɗa Jardiance da ɗayan waɗannan magungunan ba laifi bane muddin ana sa ido kan sikari na jini akai-akai.

A ƙarshe, Jardiance yana saukar da hawan jini . Baya ga cire glucose ta fitsari, Jardiance da makamantan kwayoyi kuma suna tace sinadarin sodium, yana rage yawan sinadarin sodium na jiki. Saboda wannan dalili, Jardiance ya kamata a kula a hankali tare da magungunan hawan jini. Ba wai kawai haduwar na kara barazanar kamuwa da cutar hawan jini ba, amma wasu magunguna masu hawan jini kuma suna haifar da kasadar rashin sukarin jini ko wasu illoli.

Yadda za a guje wa tasirin Jardiance

Duk magunguna suna da sakamako masu illa. Duk da yake ba za a iya hana illa ba gaba ɗaya, tipsan shawarwari na iya taimakawa wajen sarrafa ko rage tasirin tasirin Jardiance:

1. Jarauki Jardiance kamar yadda aka umurta

Theauki sashi da aka tsara. Idan ka rasa kashi, kar a dauki karin magani don gyara shi. Idan maganin baiyi kamar yana aiki ba ko kuma illolin suna da wahalar iyawa, yi magana da likitan da yake rubutawa game da canza maganin ko sauya zuwa wani sabon magani.

2. Faɗa wa likitan lafiyarka game da duk yanayin lafiyar ka da magungunan ka

Saboda haɗarin illa, yakamata ka gayawa maikatan lafiyarka game da:

• Duk wani yanayi na zahiri da kake da shi, musamman zuciya, wurare dabam dabam, hawan jini, pancreas, koda, ko matsalolin hanyoyin fitsari
• Duk magungunan da kake sha yanzu kuma
• Duk magungunan kan-kan-counter, kari, da magungunan ganye da kuke sha

Yi magana da likita koyaushe, likitan magunguna, ko wani ƙwararren masanin kiwon lafiya, idan kun sami lahani yayin shan Jardiance.

3. Kula da suga

Jardiance yawanci ana sanya shi azaman magani na biyu tare da sauran magungunan ciwon sukari da suka haɗa da insulin, metformin, pioglitazone, ko sulfonylurea. Jardiance, musamman idan aka haɗe shi da wasu magungunan ciwon sikari, na iya haifar da ƙarancin sukarin jini mai haɗari. Mai ba ku kiwon lafiya na iya tambayar ku a kai a kai su lura da jinin ku. Har ila yau, ya kamata ku kasance a farke don alamun rashin ƙaran sukari a cikin jini kamar bugun zuciya da sauri, kodadde fata, gajiya, damuwa, gumi, rawan jiki, ƙaiƙayi, rikicewa, ko yunwa. Aauki tushen suga mai sauri kuma mai yiwuwa neman shawarar likita.

4. Kula da hawan jini

Jardiance yana da tasiri kwatankwacin mai ƙyama, don haka yana iya rage girman jini da hawan jini. Kasance cikin nutsuwa wajan bayyanar da alamomin cutar hawan jini kamar su jiri yayin tashi tsaye, suma, ciwon kai, yawan bacci, hangen nesa, tashin zuciya, sanyi, fata mai matse jiki. Idan kuna fuskantar matsaloli tare da saukar karfin jini lokacin shan Jardiance, yana iya taimakawa siyan na'urar hawan jini kuma saka idanu akai akai da yin rikodin jinin ku.

Albarkatun:

• Rahoton Nazarin Clinical: Empagliflozin (Jardiance), Canadianungiyar Kanada ta Magunguna da Fasaha a Lafiya
• Empagliflozin , StatPearls
• Bayanin mahaɗan Empagliflozin , National Library of Medicine
• Gangrene ta Hudu , Organizationungiyar forasa ta Rare Rarraba
• Hypoglycemia bayyanar cututtuka , EndocrineWeb
• Jardiance , Munafukai
• Takardar Bayanin Jardiance , Shire US
• Jagorar Magungunan Jardiance , Boehringer Ingelheim