Main >> Magunguna Vs. Aboki >> Amitiza vs. Linzess: Bambanci, kamance, kuma wanne ne mafi alheri a gare ku

Amitiza vs. Linzess: Bambanci, kamance, kuma wanne ne mafi alheri a gare ku

Magunguna vs. Aboki

Amitiza da Linzess wasu magunguna ne guda biyu da aka yi amfani da su wajen magance cututtukan maƙarƙashiya na yau da kullun (CIC) da cututtukan hanji tare da maƙarƙashiya (IBS-C). Ciwan ciki na yau da kullun yana iya kasancewa na tsawon watanni shida ko ya fi tsayi tare da uku ko weran motsin hanji na mako-mako. Ciwon hanji mai haɗari rukuni ne na alamomi daban-daban da ke faruwa tare haɗe da ciwon ciki da canje-canje a cikin hanjin ciki: gudawa, maƙarƙashiya, ko duka biyun. Amitiza da Linzess ana amfani dasu musamman a cikin IBS tare da maƙarƙashiya. Zamu tattauna kamanceceniya da banbanci tsakanin Amitiza da Linzess anan.

Menene manyan bambance-bambance tsakanin Amitiza da Linzess?

Amitiza (lubiprostone) magani ne na likitanci wanda ke kula da maƙarƙashiya ta hanyar ƙara ɓoye ruwan hanji. Yana da acid mai ƙwan keke da furotin E1 (PGE 1) wanda ke kunna tashoshin chloride a cikin rufin hanji. Sakamakon karuwa a cikin ɓoye yana canza daidaiton kujeru kuma yana haɓaka motsi na ciki na yau da kullun. Amitiza yana samuwa azaman kwantaccen softgel na kwaskwarima cikin ƙarfin 8 mcg da 24 mcg.

Linzess (linaclotide) magungunan ƙwayoyi ne kuma an nuna su don magance maƙarƙashiya. Yana da agonist mai guanylate cyclase C (GC-C) wanda ke haifar da ƙaruwa a cikin guanosine monophosphate na cyclic (cGMP). Ayyuka a mai karɓar GC-C yana haifar da ƙaruwa a ɓoye ɓoyayyen hanji. Wannan yana haifar da ƙaruwar ruwan hanji kuma yana ƙaruwa da motsin abubuwan hanji ta hanyar fili. Thoughtara yawan matakan cGMP ana kuma tunanin sasanta raunin visceral a cikin ciki wanda aka saba da shi a cikin IBS. Ana samun Linzess azaman kwantaccen baka cikin ƙarfin 72 mcg, 145 mcg, da 290 mcg.

Babban bambance-bambance tsakanin Amitiza da Linzess
	Amitsawa	Linzess
Ajin magani	Bicyclic fatty acid / PGE 1 wanda aka samu / chloride tashar activator	Guanylate cyclase C agonists
Alamar alama / ta kowa	Nau'i kawai	Nau'i kawai
Menene sunan gama-gari?	Lubiprostone	Linaclotide
Wani nau'i (s) ne miyagun ƙwayoyi ya shigo?	Oral softgel kwantena	Maganin baka
Menene daidaitaccen sashi?	24 mcg sau biyu a rana	145 mcg sau ɗaya kowace rana
Yaya tsawon maganin al'ada?	Ba shi da iyaka, tsawon lokaci	Ba shi da iyaka, tsawon lokaci
Wanene yawanci yake amfani da magani?	Manya	Manya

Yanayin da Amitiza da Linzess suka kula da su

Amitiza da Linzess kowannensu an nuna shi a cikin maganin cututtukan ciki na yau da kullun da kuma rashin ciwon hanji tare da maƙarƙashiya. Amitiza kuma ya yarda da Abinci da Magunguna (FDA) a cikin maganin maƙarƙashiyar da ta haifar da amfani da cututtukan opioid a cikin ciwo mai tsanani, ba na ciwon daji ba. Wannan wani lokaci ana kiransa OIC, maƙarƙashiyar da ke haifar da opioid.

Amitiza da Linzess ana nuna kowannensu kawai don amfani a cikin manya, kuma ba a yarda da amfani da yara da matasa ba. Kwararrun likitan ku kawai zasu iya yanke shawara idan waɗannan magunguna sune zaɓin da ya dace don yanayin ku.

Yanayi	Amitsawa	Linzess
Ciwan ciki na rashin lafiya na yau da kullun	Ee	Ee
Ciwon hanji mai saurin fushi tare da maƙarƙashiya	Ee	Ee
Iunƙwasa mai saurin tashin hankali (rashin ciwo, rashin ciwon daji)	Ee	Ba

Shin Amitiza ko Linzess sun fi tasiri?

ZUWA nazari na yau da kullun na 21 bazuwar gwajin gwaji na asibiti idan aka kwatanta da sinadaran aiki na Amitiza, Linzess, da sauran magungunan maƙarƙashiya gama gari. Sauran jiyya da aka haɗa a cikin wannan binciken sune prucalopride, tegaserod, bisacodyl, da polyethylene glycol (PEG). Wannan binciken ya kammala cewa duk sun hada da kwayoyi sun nuna irin wannan ingancin akan placebo lokacin kimanta makasudin samun 3 ko fiye da haka hanji motsawa kowane mako. Bisacodyl, mai yawan amfani da laxative mai saurin tashin hankali, ya fi duka Amitiza da Linzess dangane da canji a yawan jujjuyawar ciki a kowane mako. Xananan laxatives na iya haifar da rashin daidaiton lantarki kuma suna fuskantar ci gaban haƙuri cikin lokaci.

Mai ba da magani na iya buƙatar yin la'akari da dalilai kamar abubuwa masu haɗari, haɗuwa da ƙwayoyi, da kuma yarda da sau ɗaya kowace rana ko sau biyu kowace rana yayin yanke shawarar wane magani ne mafi kyau ga mai haƙuri.

Verageaukar hoto da kwatancen farashi na Amitiza vs. Linzess

Amitiza yawanci ana rufe shi ne ta hanyar kasuwanci da shirin magunguna na Medicare Part D, kodayake a wasu lokuta yana iya buƙatar izinin farko don ɗaukar hoto. Farashin aljihu don Amitiza na iya kai kimanin $ 282, amma takaddun shaida daga SingleCare na iya rage farashin zuwa kusan $ 176 don samar da kwanaki 30.

Linzess yawanci ana rufe shi ne ta hanyar kasuwanci da shirin magunguna na Medicare Part D, kodayake a wasu lokuta yana iya buƙatar izinin farko don ɗaukar hoto. Ba tare da kowane irin ɗaukar hoto ba, Linzess na iya cin kusan $ 640. Kwancen Linzess daga SingleCare zai taimaka maka adana akan Linzess, kuma zaka iya biyan kuɗi kaɗan kamar $ 395.

	Amitsawa	Linzess
Yawanci inshora ya rufe?	Ee, wani lokacin tare da izinin izini da ake buƙata	Ee, wani lokacin tare da izinin izini da ake buƙata
Yawanci an rufe shi ta Medicare Part D?	Ee, wani lokacin tare da izinin izini da ake buƙata	Ee, wani lokacin tare da izinin izini da ake buƙata
Yawan	30, 24 mcg kwantena	30, 145 mcg kwantena
Hanyar biyan kuɗaɗe na Medicare	Ya bambanta dangane da shirin	Ya bambanta dangane da shirin
SingleCare kudin	$ 176– $ 204	$ 395– $ 470

Sami katin rangwame na kantin magani

Sakamakon illa na yau da kullun na Amitiza vs. Linzess

Amitiza da Linzess suna da wasu matsaloli na yau da kullun tsakanin su, amma kuma wasu sun fi dacewa da kowane magani. Cutar gudawa ita ce mafi mahimmanci dalilin dakatar da magani ga magungunan duka, kuma yana da tasiri na gama gari ga duka magungunan.

Amitsawa yana iya haifar da tashin zuciya, yana faruwa a kusan ɗaya cikin kowane marasa lafiya ukun da suke shan maganin. Wannan yana faruwa sau da yawa idan aka ɗauke shi akan komai a ciki. Wani lokaci wannan tashin zuciya yana da tsanani da rauni, yana kiyaye marasa lafiya daga ayyukan yau da kullun. Magunguna akan Amitiza sun ba da rahoton abubuwan da suka faru kamar su dizziness, gajiya, da ciwon kirji, yayin da marasa lafiya a Linzess ba su bayar da rahoton waɗannan tasirin ba.

Wannan ba ana nufin ya zama cikakken jerin abubuwan illa ba, don Allah tuntuɓi likitan ku ko likitan magunguna don cikakken jeri.

	Amitsawa	Linzess
Sakamakon sakamako	Ana amfani?	Mitar lokaci	Ana amfani?	Mitar lokaci
Ciwan	Ee	29%	Ee	<2%
Gudawa	Ee	12%	Ee	16-20%
Ciwon kai	Ee	goma sha ɗaya%	Ee	4%
Ciwon ciki	Ee	8%	Ee	7%
Cushewar ciki / kumburin ciki	Ee	6%	Ee	2-3%
Ciwan ciki	Ee	6%	Ee	4-6%
Amai	Ee	3%	Ee	<2%
Edema	Ee	3%	Ba	n / a
Ciwan ciki	Ee	3%	Ba	n / a
Dizziness	Ee	3%	Ba	n / a
Ciwon kirji	Ee	kashi biyu	Ba	n / a
Dyspnea	Ee	kashi biyu	Ba	n / a
Dyspepsia	Ee	kashi biyu	Ee	<2%
Gajiya	Ee	kashi biyu	Ba	n / a
Bakin bushe	Ee	1%	Ba	n / a

Source: Amitiza ( DailyMed ) Linzess ( DailyMed )

Hadin magunguna na Amitiza vs. Linzess

Amitiza da Linzess ya kamata a yi amfani da su a hankali a kan marasa lafiya kan kwayoyi tare da magungunan anticholinergic. Magungunan Anticholinergic na iya haɓaka maƙarƙashiya kuma su yi tsayayya da ayyukan magani na Amitiza da Linzess.

Marasa lafiya waɗanda ke kan diuretics, kamar furosemide (Lasix), ya kamata su guji Amitiza saboda suna iya fuskantar haɗarin rasa sanadarin mai yawa (hypokalemia). A cikin waɗannan marasa lafiya, Linzess na iya zama zaɓin da aka fi so.

Wannan ba cikakken lissafi bane na hulɗar miyagun ƙwayoyi ba. Don cikakken jeri, da fatan za a nemi shawarar likitan ku na likitan ku na gastroenterology.

Drug	Ajin magani	Amitsawa	Linzess
Atropine Belladonna Benztropine Chlordiazepoxide Dicyclomine Flavoxate Glycopyrrolate Homatropine Hyoscyamine Methscopolamine Oxybutynin Scopolamine	Anticholinergics	Ee	Ee
Bismuth salicylate Loperamide	Ciwon mara	Ba	Ee
Bumetanide Furosemide Torsemide	Madauki madaukai	Ee	Ba
Lactulose	Laxative	Ee	Ba
Solifenacin	Antimuscarinic	Ee	Ba
Methadone	Opioid	Ee	Ba

Gargaɗi na Amitiza da Linzess

Amitiza na iya haifar da matsanancin jiri. Abin da ya faru na tashin zuciya na iya raguwa ta shan Amitiza da abinci.

Bai kamata a ba Amitiza da Linzess ga marasa lafiyar da ke fama da zawo mai tsanani ba saboda wannan na iya haifar da gudawar da ta tsananta. Idan gudawa ta fara bayan ka fara jiyya, ka daina magani, sai ka tuntubi likitocin ka.

Syncope, ko jiri a tsaye, da hauhawar jini, ko ƙaran jini, na iya faruwa bayan fara Amitiza. Marasa lafiya ya kamata su kula da hawan jinin su kuma tashi a hankali daga wurin zama don kaucewa faɗuwa. Sanar da likitanka game da duk wani yanayin kiwon lafiya ko wasu ƙwayoyi da zaka iya sha wanda zai iya haifar da matsala tsakanin aiki tare.

Dyspnea, ko jin matsin kirji da gajeren numfashi, na iya faruwa tare da Amitiza. Wannan alamun yana saitawa a cikin 30 zuwa 60 minti na kashi kuma yana iya wucewa na 'yan awanni. Idan wannan ya faru, ya kamata ka tuntuɓi likitanka.

Linzess tana ɗauke da gargaɗin dambe da rashin fa'ida game da amfani da marasa lafiyar yara saboda iyawarta na haifar da rashin ruwa mai ƙarfi. Ana iya samun ƙarin bayani game da wannan gargaɗin a fda.gov .

Tambayoyi akai-akai game da Amitiza vs. Linzess

Menene Amitiza?

Amitiza magani ne da aka yi amfani da shi don magance cututtukan maƙarƙashiya na yau da kullun kuma a cikin maganin cututtukan hanji tare da maƙarƙashiya. Amitiza kuma an yarda da shi don magance amfani da maƙarƙashiya da ke haifar da opioid don ciwo na yau da kullun, rashin ciwon daji. Yana aiki ta hanyar haɓaka ɓoyayyun hanji don canza daidaiton kujerun. Ana samuwa azaman kwantaccen baka a cikin 8 mcg da 24 mcg ƙarfi.

Menene Linzess?

Linzess magani ne da aka ba da magani wanda aka nuna a cikin maganin ciwon ciki na yau da kullun da rashin ciwon hanji tare da maƙarƙashiya. Yana kara ruwan hanjin ciki da wucewa. Akwai shi a cikin kwantena na baka cikin ƙarfin 72 mcg, 145 mcg, da 290 mcg.

Shin Amitiza da Linzess iri daya ne?

Duk da yake Amitiza da Linzess kowannensu na maganin maƙarƙashiya, ba su ɗaya ba. Amitiza shine mai keɓaɓɓen fatty acid da prostaglandin E1 (PGE 1), kuma ana shan shi sau biyu a rana. Linzess na cikin ɗalibai na aganists na guanylate cyclase C (GC-C), kuma ana amfani da ita sau ɗaya kowace rana.

Shin Amitiza ko Linzess sun fi kyau?

Amitiza da Linzess sun nuna irin wannan ingancin don magance maƙarƙashiya. Masu ba da labari za su iya yin la'akari da dalilai kamar su dosing regimens da abubuwa marasa kyau yayin yanke shawarar wane magani ne mafi kyau ga mai haƙuri. Amitiza da Linzess sun fi son kasancewa cikin maƙarƙashiya na yau da kullun saboda wasu hanyoyin maganin gargajiya kamar su masu laushi (misali docusate), masu jinƙai na osmotic (misali Miralax), ko masu laulai masu motsa jiki (misali senna) na iya haifar da raunin rashin daidaiton lantarki da haɓaka haƙuri tare da amfani na dogon lokaci.

Shin zan iya amfani da Amitiza ko Linzess yayin da nake da juna biyu?

Ba a ƙaddara haɗarin haɗarin ƙwayoyi don amfani da Amitiza ko Linzess ba saboda babu wadataccen, gwajin gwaji na asibiti don tabbatar da amincin su. Amfani da waɗannan ƙwayoyi a cikin ciki ya kamata a iyakance ga yanayi inda fa'idodi ya wuce haɗarin.

Zan iya amfani da Amitiza ko Linzess tare da barasa?

Babu wata takaddama kai tsaye don shan wadannan kwayoyi da shan giya, amma, yana da muhimmanci a kula cewa giya na iya haifar da rashin ruwa da gudawa, kamar yadda wadannan kwayoyi suke, suna sanya marasa lafiya cikin hadari mai tsanani.

Shin Amitiza tana haifar da karin kiba?

Ba a nuna Amitiza don haifar da ƙimar kiba ba.

Yaya tsawon lokacin da za a yi wa Linzess aiki?

Saukewar maƙarƙashiya gabaɗaya yana faruwa tsakanin mako ɗaya zuwa biyu, tare da ci gaba da ci gaba a cikin alamun da ke faruwa har zuwa makonni 12.

Wanene bai kamata ya sha Amitiza ba?

Marasa lafiya waɗanda ke da toshewa ta hanyar inji (GI) bai kamata su sha Amitiza ba. Hakanan, marassa lafiyar da ke fuskantar gudawa zuwa matsakaici mai tsanani ba za su sha Amitiza ba. Mata masu juna biyu ko masu shayarwa, da kuma marasa lafiyar yara, su guji Amitiza.