Latuda side effects da yadda ake kaucewa su

Bayanin Magunguna

Latuda sakamako masu illa | Karuwar nauyi | Janyewa | Har yaushe tasirin sakamako zai wuce? | Gargadi | Abubuwan hulɗa | Yadda ake kauce wa illoli

Latuda (sinadari mai amfani: lurasidone hydrochloride) sanannen sanannen antipsychotic ne wanda aka amince da shi don magance schizophrenia a cikin samari da manya da kuma kula da ɓacin rai a cikin manya da yara 10 ko mazan da aka gano da cutar bipolar. Hakanan za'a iya haɗa shi da lithium ko valproate don magance bipolar ciki a cikin manya. Lurasidone, mai aiki a cikin Latuda, yana shafar ayyukan dopamine da serotonin, sunadarai da ke taimakawa wuce sigina tsakanin jijiyoyi. Kamar duk magungunan da ke canza ilimin sunadarai na kwakwalwa, Latuda na iya haifar da sakamako masu illa, taɓar da wasu yanayin kiwon lafiya, da hulɗa tare da wasu magunguna.

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Sakamakon illa na yau da kullun na Latuda

Kamar dukkanin magunguna, Latuda na iya haifar da ƙananan sakamako na wucin gadi ko na ɗan lokaci. Fiye da 1 cikin mutane 20 za su sami sakamako masu illa kamar su bacci, tashin zuciya, tashin hankali, tashin hankali, ko motsawa ba da son rai ba.

A cikin marasa lafiya da ke shan Latuda, yawancin cututtukan da aka ruwaito sune:

• Ciwan
• Akathisia (buƙatar da ba za a iya motsawa ba don motsawa)
• Exrapyramidal bayyanar cututtuka (rawar jiki, girgiza, motsi ba da son rai ba, nutsuwa)
• Matsalar motsi ko jinkirin motsi
• Bacci
• Bacci
• Rashin bacci
• Bakin bushe
• Gudawa
• Cutar ciki
• Amai
• Tashin hankali
• Gaggawa
• Cutar hanci
• Duban gani

Yawancin illoli masu yawa suna daidaitawa-gwargwadon ƙimar, yawan haɗari da ƙarancin sakamako masu illa. Nemi shawarar likita idan kun sami wasu ƙananan lahani yayin shan Latuda.

M sakamako mai tsanani na Latuda

Duk magungunan antipsychotic na iya haifar da sakamako mai tsanani da dogon lokaci. Babban sakamako mai illa Latuda sun hada da:

• Canje-canje na rayuwa wanda ke haifar da hauhawar jini, hauhawar triglycerides, haɓakar cholesterol, ƙarancin sodium, ko ciwon sukari
• Hyperthermia
• Wuce haddi prolactin
• Rage cikin farin ƙwayoyin jini
• Matsalar haɗiye
• Ciwon ƙwayar cuta na Neuroleptic
• Marigayi dyskinesia
• Mania
• Tunani da halaye na kisan kai
• Kamawa
• Buguwa
• Mutuwa

Kamar sauran magunguna masu kwantar da hankali, Latuda na iya haifar da canje-canje na rayuwa da riba mai nauyi, kodayake wannan ba shi da sauƙi kuma ba a bayyana shi sosai da irin magungunan. Latuda bazai iya zama madaidaicin magani ga mutanen da ke da tarihin iyali na ciwon sukari ko ciwo na rayuwa ba.

Duk magunguna masu tabin hankali suna tsoma baki tare da ikon jiki don daidaita yanayin zafin jiki. Sakamakon haka, mutanen da ke shan Latuda suna cikin haɗarin kamuwa da cutar zafi mai zafi (hyperthermia), yanayin lafiyar da ke barazana ga rayuwa. Dole ne a yi hankali don kauce wa yanayin zafi ko wuce gona da iri yayin shan Latuda.

Latuda tana ƙara haɗarin tunanin kashe kai da halaye a cikin yara, matasa, da matasa waɗanda ake kula da su don ɓacin rai. Lokacin ba da Latuda don damuwa, yana da mahimmanci a kula da alamun kisan kai ciki har da:

• Ra'ayin kashe kansa ko sharhi
• Attoƙarin kashe kansa
• Canjin yanayi
• Fushi, bacin rai, ko ta'adi
• Depressionarin baƙin ciki
• Anxietyarin damuwa
• Hare-hare tsoro
• Halin ɗaukar haɗari

Sauran cututtukan cututtuka masu haɗari da rikitarwa daga Latuda da yawan amfani da magungunan antipsychotic sun haɗa da:

• Hyperprolactinemia
• Tsarin orthostatic
• Dysphagia
• Ciwon ƙwayar cuta na Neuroleptic
• Marigayi dyskinesia

Yawancin magunguna masu kwantar da hankali suna rage ƙofar kamawa, suna sanya marasa lafiya cikin haɗarin haɗari saboda wasu dalilai. A cikin gwaji na asibiti , marasa lafiya da ke shan Latuda suna da rauni kaɗan na raguwa, yana mai sanya Latuda ƙananan ƙwayoyi masu haɗari don haifar da kamuwa da cuta. Koyaya, maƙerin, Sunovion Pharmaceuticals Inc., ya ba da shawarar cewa a yi amfani da Latuda cikin taka tsantsan a cikin marasa lafiyar da ke da tarihin kamuwa da cutar.

A ƙarshe, Latuda ta haɓaka haɗarin bugun jini da mutuwa ga marasa lafiya sama da shekaru 65 tare da hauka mai nasaba da tabin hankali. Saboda wannan dalili, ba a yarda da Latuda ta magance tabin hankali da ke da nasaba da cutar ƙwaƙwalwa ba.

Latuda karin nauyi

Magungunan antipsychotic yawanci suna haifar da canje-canje na rayuwa da riba mai nauyi azaman illolin da ba'a so, amma yawancin karɓar nauyi ya bambanta da magani. Koyaya, bisa ga gwajin gwajin asibiti guda ɗaya da aka lissafa a sama, Latuda ya ci nasara a ƙananan ƙarshen, yana haifar da karɓar nauyin nauyin kusan fam guda ɗaya a cikin gajeren lokaci kuma kimanin fam biyu a cikin dogon lokaci (shekara guda). Kusan 4.8% na marasa lafiya a cikin wannan gwajin sun sami sama da 7% na nauyin jiki dangane da 3.3% waɗanda ke shan placebo.

Abin da duk wannan ke nufi shi ne cewa haɗarin ƙaruwa lokacin shan Latuda ya ƙasa da yadda yake tare da sauran maganin ƙwaƙwalwa. Wannan shi ne saboda tasirin rauni na Latuda akan wasu nau'ikan masu karɓar jijiyoyin da wasu magungunan antipsychotic ke hulɗa da su. A sakamakon haka, illolin da ke tattare da mutum kamar nauyi mai nauyi, rawar jiki, da hauhawar jini ba su da yawa kuma ba su da ƙarfi sosai fiye da sauran magungunan ƙwayoyin cuta. Koyaya, masana'anta sun ba da shawarar cewa a kula da nauyin a hankali yayin shan Latuda.

Latuda janyewa

Babu karatu ko gwaji na asibiti da ke mayar da hankali kan bayyanar cututtukan Latuda, kodayake akwai rahotanni na ficewar Latuda. Babu masana'antun ko Takaddun Shafin Likitan da suka ayyana ficewa a matsayin sakamako na gefe ko kuma bayar da shawarar tsarin ƙoshin magani yayin dakatar da Latuda.

Koyaya, magungunan kwantar da hankali waɗanda ke aiki iri ɗaya kamar Latuda, waɗanda ake kira antagonists na dopamine, na iya haifar da bayyanar cututtuka lokacin da aka daina su, amma ba duk marasa lafiya bane zasu sami tasirin cirewa lokacin daina dakatar da cututtukan atypical. Wadanda suke yin hakan na iya fuskantar rashin saurin bayyanar cututtuka. Duk da haka, da Psyungiyar chiwararrun Americanwararrun Amurka yana bada shawarar rage kashi ta 10% kowane wata yayin daina dakatar da shan magungunan kashe kumburi don rage hadarin janyewa ko kuma bayyanar cututtuka.

Mafi yawan alamun bayyanar janyewar lokacin dakatar da maganin ƙwaƙwalwar ƙwaƙwalwa shine alamar bayyanar. Idan mai haƙuri ya kasance ba shi da wata alama ta ɗan lokaci, dawowar bayyanar cututtuka na iya zama mafi muni fiye da kafin magani. Sauran cututtukan cututtukan da ke dauke da cutar sun hada da motsa jiki ba tare da son rai ba, juyawa, saurin motsi, tilasta motsawa, tashin zuciya, amai, gudawa, da ciwon ciki. Mai ba da sabis na kiwon lafiya na iya ba da umarnin magungunan Parkinson don sauƙaƙe janyewar antipsychotic.

Har yaushe tasirin tasirin Latuda zai wuce?

Illolin sakamako na iya ɗauka muddin ana ɗaukar Latuda, amma wasu ƙananan illolin na iya raguwa a kan lokaci. Bayan jinya na dogon lokaci, Latuda zai ɗauka kwana biyu zuwa hudu don sharewa gaba daya daga jiki. Yawancin ƙananan abubuwa da wasu mawuyacin sakamako masu illa zasu fara warwarewa game da wannan lokacin. Abun takaici, wasu cututtukan sakamako masu tsanani na iya ɗaukar lokaci don warwarewa wasu kuma, kamar su dyskinesia na tardive, na iya zama ba za'a iya sauyawa ba.

Latuda sabawa & gargaɗi

Latuda ta zo tare da gargadin akwatin baki na FDA cewa ba za a yi amfani da ita ba wajen magance tabin hankali da ke da nasaba da cutar ƙwaƙwalwa saboda haɗarin mutuwa ko bugun jini. Hakanan bai kamata a ɗauke Latuda ta:

• Mutanen da suke rashin lafiyan lurasidone ko wani kayan aikin sa masu aiki
• Mutanen da ke shan ƙwayoyi ko abubuwan da za su tsoma baki sosai game da tasirin jiki na lurasidone

Sauran gargaɗin sun haɗa da:

• Ciwon ƙwayar cuta na Neuroleptic
• Marigayi dyskinesia
• Whiteananan ƙwayoyin jinin jini sun ƙidaya
• Tsarin orthostatic
• Tunani ko halaye na kisan kai
• Hawan jini, mai, ko cholesterol

Yara

Latuda tana kula da matasa masu shekaru 13 zuwa sama don cutar schizophrenia da yara da matasa da suka girmi shekaru 10 don ɓacin rai. Ba a yi nazarin lafiyar Latuda a cikin yara ƙanana ba 10.

Lokacin da aka yi amfani da shi don magance baƙin ciki, Latuda ta haɓaka haɗarin tunanin kashe kai da halaye a cikin yara da matasa. Yara da matasa marasa lafiya ya kamata a kula dasu saboda mummunan ɓacin rai ko alamu na kisan kai.

Ciki da shayarwa

Babu karatun aminci game da amfani da Latuda a cikin mata masu ciki ko uwa masu shayarwa. Akwai bayanan shaidar jarirai waɗanda ke da rikicewar motsi da alamun bayyanar lokacin da aka ɗauki maganin ƙwaƙwalwa a cikin watanni uku na ciki. Ana iya ɓoye Latuda a cikin nono, amma ba a tantance ainihin adadin ba. Kamar kowane magani mai kwantar da hankali, mata yakamata su tattauna fa'idodi da illolin shan Latuda yayin da suke ciki ko jinya.

Tsofaffi

Ba a yi nazarin lafiyar Latuda a cikin mutanen da suka wuce shekaru 65 sosai ba kuma bayanin da ke bayarwa yana yin taka tsantsan wajen yin rubutu a cikin tsofaffi (mai shekara 65 da sama) Sabili da haka, zaɓin da za a rubuta wannan magani a cikin shekarun 65 zuwa sama, tare da ganewar cutar schizophrenia ko ɓacin rai, ana yin su ne bisa la'akari da shari'ar tare da tuntuɓar mai ba da kiwon lafiya. Latuda tana haifar da haɗarin bugun jini da mutuwa a cikin tsofaffi marasa lafiya da ke da larurar hauka, don haka ba a yarda da Latuda ga waɗannan marasa lafiya ba.

Hulɗar Latuda

Ga magunguna kamar Latuda, hulɗar magungunan ƙwayoyi suna da rikitarwa da rikicewa. Don sauƙaƙa hulɗar Latuda, bai kamata a ɗauki wasu kwayoyi ba ko kuma a yi a hankali saboda za su iya:

• Tsoma baki tare da ikon jiki don lalata lurasidone, sinadaran aiki a cikin Latuda ko
• Effectsarin sakamako masu illa

CYP3A4 masu haɓakawa da masu hanawa

An hana Latuda amfani da magunguna masu ƙarfi CYP3A4 masu haɓakawa da masu hanawa. A sauƙaƙe, waɗannan magungunan ko dai suna hanzarta lalacewar lurasidone ta jiki (CYP3A4 inducers) ko hanawa da rage saurin lurasidone (masu hana CYP3A4).

Magungunan da zasuyi saurin faduwa da lurasidone zasu rage tasirin ta sosai. Wadannan sun hada da:

• St John's wort
• Maganin rigakafi : rifampin, rifaximin, da rifamycin
• Wasu nau'ikan anticonvulsants : carbamazepine, phenytoin, primidone, da fosphenytoin
• Barbiturates : pentobarbital da phenobarbital
• Dexamethasone, Lysodren (mitotane), Xtandi (enzalutamide), Erleada (apalutamide), Orkambi (lumacaftor), da Rydapt (midostaurin)

Ana iya sha da ƙwayoyi waɗanda kawai suke matsakaita saurin rauni na lurasidone, amma likitoci na iya buƙatar gyara magani ko yawan adadinsu.

Magunguna da abinci waɗanda ke rage tasirin metabolism na lurasidone, duk da haka, suna ƙara yawan hankalin Latuda a cikin jini kuma don haka yana ƙara haɗarin illa. Theananan masu hanawa waɗanda ba za a taɓa ɗauka tare da Latuda sun haɗa da:

• Garehul, curcumin, da zinariya
• Wasu nau'ikan maganin rigakafi : clarithromycin, erythromycin, troleandomycin, da telithromycin
• Magungunan antifungal (azole) : econazole, ketoconazole, voriconazole, methimazole, da posaconazole
• Magungunan hawan jini : diltiazem da verapamil
• Wasu nau'ikan magungunan maganin cutar : ritonavir, atazanavir, darunavir, lopinavir, efavirenz, tipranavir, Incivek (telaprevir), Invirase (saquinavir), Rescriptor (delavirdine), Crixivan (indinavir), Vitekta (elvitegravir), Victoria
• Wasu nau'ikan tsarin garkuwar jiki da ke canza magungunan anticancer kamar Tasigna (nilotinib), Kisqali (ribociclib) Zydelig (idelalisib), da Rydapt (midostaurin)
• Ergotamine, terfenadine, nefazodone, loperamide, cobicistat, Vaprisol (conivaptan), Diacomit (stiripentol), naloxone, danazol, da lonafarnib

Aba hasa tana da abubuwa waɗanda su ma masu hana CYP3A4 ne. Koyaya, waɗannan abubuwan ba sa tsoma baki tare da ikon jiki don yin amfani da lurasidone a cikin jiki, amma dai toshe wannan tsari a cikin hanjin . Wannan yana nufin cewa jiki yana shan lurasidone fiye da yadda yake a koyaushe, yana ƙara haɗarin illa. Illar inabi a ƙwayoyin hanji na iya ɗaukar tsawon sa’o’i 24, don haka ya kamata a narkar da ‘ya’yan inabi gaba ɗaya yayin shan Latuda.

Masu damuwa

Latuda ita ce tsarin juyayi ta tsakiya. Yana rage kwakwalwa. Wadannan tasirin zasu inganta idan aka dauki Latuda tare da wasu masu damuwar tsarin juyayi. Illolin na iya zama masu haɗari ga jiki. Idan ba su ba, gajiya da asarar ikon motsi na iya ƙara haɗarin haɗari ko rauni. Lokacin shan Latuda, yakamata a guji ko amfani da sauran masu damuwa na CNS cikin hankali ciki har da:

• Barasa, marijuana, cannabinoids, ginseng, ko Gotu kola
• Antihistamines kamar su Benadryl (diphenhydramine), doxylamine, da pheniramine
• Narcotics kamar su codeine, morphine, ko tramadol
• Sedatives (kayan bacci) kamar midazolam ko estazolam
• Magungunan damuwa kamar buspirone ko diazepam
• Magungunan ciwo na jijiya kamar gabapentin, gabapentin enacarbil, ko pregabalin
• Magungunan anti-tashin zuciya kamar metoclopramide ko ondansetron
• Anticonvulsants kamar carbamazepine ( sabawa ), phenytoin, lamotrigine, ko levetiracetam

Ba duk waɗannan magungunan za a guje musu kai tsaye ba, amma ya kamata a ɗauki duka cikin taka tsantsan kuma tare da tuntuɓar likita ko wani mai ba da kiwon lafiya. Guji tuki, injina masu aiki, ko tsunduma cikin ayyukan haɗari yayin haɗa baƙin ciki biyu na CNS.

Kamawa

Searfafawa shine rashin sarrafawa, bazuwar, da maimaita harbi na jijiyoyin jijiyoyi a cikin kwakwalwa. Zasu iya kasancewa daga fitowar hankali ta hankali zuwa raunin jiki. A cikin karatun asibiti , kamuwa sun kasance tasirin Latuda a daidai gwargwadon yadda suke don placebo, yana sanya Latuda ta kasance mai amintaccen magani mai maganin ƙwaƙwalwa. Har yanzu, Latuda da duk sauran magungunan maganin ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ajiya, suna sanya marasa lafiya cikin haɗarin kamuwa da cuta. A saboda wannan dalili, masu ba da sabis na kiwon lafiya za su guji haɗa Latuda tare da magunguna waɗanda ke iya haifar da kamuwa ciki har da Firdapse (amifampridine), Wellbutrin (bupropion), da wasu nau'ikan magungunan da ake amfani da su don X-ray ko wasu hotunan.

Latuda na iya yin ma'amala da wasu magunguna da yanayi kamar:

• Magungunan Parkinson
• Hypglycemia
• Ciwan zafin jiki

Yadda za a kauce wa tasirin Latuda

Antipsychotics kamar su Latuda galibi suna haifar da sakamako masu illa. Wani lokaci, waɗannan tasirin na haifar da marasa lafiya su daina shan magani. Ka tuna cewa duk magungunan antipsychotic cinikayya ne tsakanin fa'idodin su sau da yawa kuma sau da yawa suna haifar da mummunan sakamako.

Bi waɗannan shawarwarin yayin shan Latuda don rage haɗarin tasirin tasirin Latuda yayin tabbatar da fa'ida mafi girma daga shan maganin:

1. Latauki Latuda kamar yadda aka umurta

Auki kashi na yau da kullum kamar yadda aka tsara. Kar a ƙara ko rage sashi. Fiye da duka, kar a ɗauki hutun kwana ɗaya ko biyu daga miyagun ƙwayoyi. Dole ne a ɗauka yau da kullun akan dogon lokaci don sanin cikakken fa'idodi. Idan maganin baiyi kamar yana aiki ba ko kuma illolin suna da wahalar iyawa, yi magana da mai bayar da maganin game da canza maganin ko sauya zuwa wani sabon magani.

2. Takeauki Latuda da abinci

Ya kamata a dauki Latuda da abinci. A zahiri, yakamata a sha tare da abincin akalla calorie 350. Duk da yake wannan bazai hana illa ba, yana tabbatar da fahimtar iyakar fa'idodi daga shan maganin.

3. Faɗa wa likitan lafiyarka game da duk yanayin lafiyar ka da magungunan ka

Saboda haɗarin illa, yakamata ka gayawa maikatan lafiyarka game da:

• Duk wani yanayin jikin da zaka iya samu, musamman
  • Hawan jini mai yawa, ciwon suga, ko kuma ciwo na rayuwa
  • Whiteananan ƙarancin ƙwayoyin jini
  • Tarihin kamuwa ko farfadiya
  • Matsalar thyroid
  • Tarihin babban matakan prolactin
  • Cutar Parkinson ko alamomi
  • Matsalar zuciya
  • Matsalar hanta
• Duk wani amfani da giya, amfani da miyagun ƙwayoyi, ko tarihin shan kwayoyi
• Duk magungunan da kake sha yanzu
• Duk magunguna da kari wadanda yawanci kuke sha

Koyaushe yi magana da mai ba da lafiyar ku game da duk wata illa da kuka samu yayin shan Latuda ko wani magani na likita.

4. Guji shan giya, antihistamines, da masu damuwa

Duk wani abu da ke rage kwakwalwa kamar giya, marijuana, antihistamines, da masu kwantar da hankali zai ƙara ɓarna tasirin lalatattun laulayi da na rashin hankali, yana haifar da haɗarin haɗari ko rauni. Lokacin shan Latuda, kar a fitar da mota, yi aiki da injina, ko kuma shiga cikin ayyukan haɗari har sai kun san yadda magungunan ke shafar ku. Hakanan yana da kyau idan aka ɗauki masu damun CNS kamar su Latuda don cire cikas da haɗari daga ko'ina cikin gida don rage haɗarin rauni na haɗari.

5. Kada a ci ‘ya’yan inabi ko shan ruwan inabi

An hana ‘ya’yan inabi da ruwan inabi lokacin shan Latuda. Aba hasa tana da abubuwa waɗanda suke ƙara yawan lurasidone da jiki ke sha, yana ƙara haɗari da tsananin tasirin illolin Latuda. Sauran kwayoyi da abubuwa na iya kara yawan hankalin Latuda a cikin jiki, don haka ka tabbata ka tattauna da mai ba da umarnin duk magunguna, kari, da magungunan ganye da ake sha.

6. Guji zafin rana

Latuda da sauran magunguna masu kwantar da hankali suna tsoma baki tare da ikon jiki don daidaita yanayin zafin jiki, yin zafin rana na iya zama haɗari. Guji zafin rana ko dehydrating ta:

• Kasancewa a cikin gida yayin yanayi mai zafi
• Gujewa wuce gona da iri ko motsa jiki
• Gujewa kasancewa cikin rana na tsawan lokaci
• Shan ruwa mai yawa
• Guji barasa - shi ma, yana shafar ikon jiki don daidaita yanayin zafin jiki

Albarkatun:

• • Latuda , Munafunci
  • Lurasidone , StatPearls
  • Takaitaccen fili na Lurasidone , National Library of Medicine
  • Lurasidone hydrochloride , PDR
  • Symptomsananan cututtukan cututtuka da ke ci gaba bayan dakatar da magungunan psychotropic , Psychotherapy da Psychosomatics
  • Gainimar nauyi mai haɗuwa da cututtukan ƙwaƙwalwa: dabarun gudanarwa da tasiri kan bin kulawa , Cututtukan Neuropsychiatric da Jiyya
  • Biochemistry, Cytochrome P450 , StatPearls
  • Canje-canjen cututtukan da ke haifar da ƙwayoyi sashi na 2: haɓakar haɓakar haɓakar ƙwayar cuta , Ciwon suga
  • Cutar da ke haifar da cutar rashin karfin jiki , Mayo Clinic
  • Mahimmancin magani na ruwan inabi da ma'amalarsa da magunguna daban-daban , Nutrition Journal
  • Yi Aikin Jagora don Maganin Schizophrenia , American Psychiatric Association
  • Marigayi dyskinesia , StatPearls